Microcapsules are versatile delivery vehicles and widely used in various areas. Generally, microcapsules with solid shells lack selective permeation and only exhibit a simple release mode. Here, we use ultrathin-shell water-in-oil-in-water double emulsions as templates and design porous ultrathin-shell microcapsules for selective permeation and multiple stimuli-triggered release. After preparation of double emulsions by microfluidic devices, negatively charged shellac nanoparticles dispersed in the inner water core electrostatically complex with positively charged telechelic α, ω-diamino functionalized polydimethylsiloxane polymers dissolved in the middle oil shell at the water/oil interface, thus forming a porous shell of shellac nanoparticles cross-linked by telechelic polymers. Subsequently, the double emulsions become porous microcapsules upon evaporation of the middle oil phase. The porous ultrathin-shell microcapsules exhibit excellent properties, including tunable size, selective permeation and stimuli-triggered release. Small molecules or particles can diffuse across the shell, while large molecules or particles are encapsulated in the core, and release of the encapsulated cargos can be triggered by osmotic shock or a pH change. Due to their unique performance, porous ultrathin-shell microcapsules present promising platforms for various applications, such as drug delivery.

微胶囊是多功能的递送载体，广泛应用于各个领域。通常，具有实心壳的微胶囊缺乏选择性渗透，仅表现出简单的释放方式。在这里，我们使用超薄壳水包油包水双乳液作为模板，设计了多孔超薄壳微胶囊，用于选择性渗透和多重刺激触发释放。通过微流控装置制备双乳液后，分散在内部水核中的带负电荷的紫胶纳米粒子与带正电荷的遥爪α，ω静电络合-二氨基官能化聚二甲基硅氧烷聚合物溶解在水/油界面的中间油壳中，从而形成由遥爪聚合物交联的虫胶纳米颗粒的多孔壳。随后，双乳液在中间油相蒸发后变成多孔微胶囊。多孔超薄壳微胶囊具有优异的性能，包括可调尺寸、选择性渗透和刺激触发释放。小分子或颗粒可以扩散穿过外壳，而大分子或颗粒被封装在核心中，并且可以通过渗透冲击或 pH 变化触发封装货物的释放。由于其独特的性能，多孔超薄壳微胶囊为各种应用提供了有前景的平台，例如药物输送。