Drug-Loaded and Anisotropic Wood-Derived Hydrogel Periosteum with Super Antibacterial, Anti-Inflammatory, and Osteogenic Activities,ACS Applied Materials & Interfaces

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Drug-Loaded and Anisotropic Wood-Derived Hydrogel Periosteum with Super Antibacterial, Anti-Inflammatory, and Osteogenic Activities
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-11-04 , DOI: 10.1021/acsami.2c12147
Jiaqing Chen ₁ , Jingsheng Chen ₁ , Zelin Zhu ₁ , Tianyi Sun ₁ , Mingxian Liu _{1,

2} , Lu Lu _{1,

2} , Changren Zhou _{1,

2} , Binghong Luo _{1,

2}

Affiliation

Current artificial periostea mainly focus on osteogenic activity but overlook structural and mechanical anisotropy, as well as the importance of antibacterial and anti-inflammatory properties. Here, inspired by the anisotropic structure of wood, the delignified wood (named white wood, WW) with a porous and highly oriented cellulose fiber skeleton was obtained, which was further filled with polyvinyl alcohol (PVA) hydrogel loaded with curcumin (Cur) and phytic acid (PA). The prepared wood-derived hydrogel composite membranes can not only exhibit an obvious anisotropic structure and good mechanical properties but also sustainably release loaded drugs to obtain long-term biological activities. Creatively, PA can effectively improve the bioavailability of Cur; more importantly, Cur and PA play an obvious synergistic effect in antibacterial, anti-inflammatory, and osteogenic activities. Compared with the wood-derived hydrogel composite membranes without drug loading, as well as loaded with Cur or PA only, these loaded with Cur and PA are significantly more conducive to inhibiting the growth of bacteria and inflammatory response and facilitating the adhesion, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells. This kind of anisotropic wood-derived hydrogel composite membrane with fantastic antibacterial, anti-inflammatory, and osteogenic activities is expected to be ideal artificial periostea.

中文翻译：

具有超强抗菌、抗炎和成骨活性的载药和各向异性木源水凝胶骨膜

目前的人工骨膜主要关注成骨活性，但忽视了结构和机械各向异性，以及抗菌和抗炎特性的重要性。在这里，受木材各向异性结构的启发，获得了具有多孔和高度定向纤维素纤维骨架的脱木素木材（命名为白木，WW），其进一步填充了负载姜黄素（Cur）的聚乙烯醇（PVA）水凝胶和植酸（PA）。制备的木源水凝胶复合膜不仅可以表现出明显的各向异性结构和良好的力学性能，而且可以缓释负载的药物，获得长期的生物活性。创造性地，PA可以有效提高Cur的生物利用度；更重要的是，Cur和PA在抗菌、抗炎和成骨活性。与未载药以及仅载Cur或PA的木源水凝胶复合膜相比，载Cur和PA的木源水凝胶复合膜更有利于抑制细菌的生长和炎症反应，促进粘附、增殖和生长。骨髓间充质干细胞的成骨分化。这种具有出色抗菌、抗炎和成骨活性的各向异性木源水凝胶复合膜有望成为理想的人工骨膜。负载Cur和PA的这些物质更有利于抑制细菌的生长和炎症反应，促进骨髓间充质干细胞的粘附、增殖和成骨分化。这种具有出色抗菌、抗炎和成骨活性的各向异性木源水凝胶复合膜有望成为理想的人工骨膜。负载Cur和PA的这些物质更有利于抑制细菌的生长和炎症反应，促进骨髓间充质干细胞的粘附、增殖和成骨分化。这种具有出色抗菌、抗炎和成骨活性的各向异性木源水凝胶复合膜有望成为理想的人工骨膜。

更新日期：2022-11-04

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