A macrocyclic lactone strategy for the synthesis of 5E-isomer-free carboprost methyl ester was developed for the first time. The macrocyclic lactone being free of 5E-isomer can be easily prepared from modified Corey lactone. The key intermediate could be used as a building scaffold to prepare carboprost methyl ester and other prostaglandins effectively.

中文翻译：

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一种不含 5E-异构体的卡前列素甲酯的新合成方法

首次开发了用于合成无 5 E异构体的卡前列素甲酯的大环内酯策略。不含5 E-异构体的大环内酯可以很容易地由改性Corey 内酯制备。该关键中间体可作为建筑支架有效制备卡前列素甲酯等前列腺素。