Sustainable Chemistry and Pharmacy ( IF 5.5 ) Pub Date : 2022-11-03 , DOI: 10.1016/j.scp.2022.100883 Arpa Petchsomrit , Naphatson Chanthathamrongsiri , Suwisit Manmuan , Nattawut Leelakanok , Nuntika Wangpradit , Boonyadist Vongsak , Thanchanok Sirirak
Buchanania siamensis is a local plant in eastern and north-eastern Thailand belonging to the Anacardiaceae family. The plant provides shading and is a good source of food and medicine since its fruits possess antioxidant and anti-cancer effects. The green, environmental-friendly, extraction of B. siamensis, under ultrasound- and microwave-assisted extraction, using solvents consisting of a variation of tween 80, propylene glycol (PG), and ethanol concentrations were investigated. Extraction by aqueous PG under ultrasound-assisted extraction (UAE) conditions yielded the highest total phenolic (TPC) and total flavonoid contents (TFC). The optimum condition, which was using a 40 mL/g ratio, 50% PG at 60°C for 20 min, yielded the extract with TPC at 49.12 ± 0.51 mgGAE/g DW and TFC at 14.18 ± 0.48 mgQE/g DW. The extract exhibited antioxidant activity at IC50 2.49 ± 0.03 mg/mL. Water-based formulations (solution and hydrogel) of this extract were successfully fabricated. The formulations demonstrated stable properties, TPC, myriscitrin, quercetrin content, and antioxidant properties after the heating and cooling test (6 cycles). Consequently, the B. siamensis extract, rich in antioxidative agents, was proper for incorporation into water-based cosmeceutical products.
中文翻译:
暹罗布坎尼亚的绿色提取和水基配方
Buchanania siamensis是泰国东部和东北部的一种本地植物,属于漆树科。这种植物提供遮荫,是很好的食物和药物来源,因为它的果实具有抗氧化和抗癌作用。暹罗双歧杆菌的绿色、环保提取,在超声和微波辅助萃取下,研究了使用由吐温 80、丙二醇 (PG) 和乙醇浓度变化组成的溶剂。在超声辅助萃取 (UAE) 条件下通过含水 PG 萃取产生最高的总酚 (TPC) 和总黄酮含量 (TFC)。最佳条件是使用 40 mL/g 比例、50% PG 在 60°C 下 20 分钟,得到的提取物 TPC 为 49.12 ± 0.51 mgGAE/g DW,TFC 为 14.18 ± 0.48 mgQE/g DW。该提取物在 IC 50下表现出抗氧化活性2.49 ± 0.03 毫克/毫升。该提取物的水基制剂(溶液和水凝胶)已成功制备。在加热和冷却测试(6 个循环)后,这些制剂表现出稳定的特性、TPC、肉豆蔻苷、槲皮苷含量和抗氧化特性。因此,富含抗氧化剂的B. siamensis提取物适合掺入水性药妆产品中。