Ag 和 Au 以外的 SERS 基底的应用趋势及其在生物分析中的作用,Biosensors

当前位置： X-MOL 学术 › Biosensors › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Ag 和 Au 以外的 SERS 基底的应用趋势及其在生物分析中的作用
Biosensors ( IF 4.9 ) Pub Date : 2022-11-03 , DOI: 10.3390/bios12110967
Alisher Sultangaziyev ₁ , Aisha Ilyas ₁ , Aigerim Dyussupova ₁ , Rostislav Bukasov ₁

Affiliation

本文比较了传统的金银基 SERS 基底和不太常规的（Pd/Pt、Cu、Al、Si 基）SERS 基底的应用，侧重于传感、生物传感和临床分析。近几十年来，大量新的生物传感和临床 SERS 应用推动了对更具成本效益、可扩展和稳定基板的研究，因为传统的金基和银基基板非常昂贵，容易腐蚀、污染和非特异性结合，特别是通过含硫化合物。之后，我们简要描述了我们在 Si 和 Al 基 SERS 衬底上的实验经验，并系统地分析了关于 Pd/Pt、Cu、Al 和 Si 等衬底材料 SERS 的文献。我们列出并讨论了品质因数，例如这些底物的分析应用的增强因子 (EF) 和检测限 (LOD)。比较结果表明，Pd/Pt衬底由于成本高而不实用；Cu 基基板不太稳定，产生较低的信号增强。Si 和 Al 基衬底显示出有希望的结果，特别是与金和银纳米结构结合使用时，因为它们可以产生与传统衬底相当的 EF 和 LOD。此外，它们的稳定性和相对较低的成本使其成为金基和银基基材的可行替代品。最后，这篇综述强调并比较了非传统 SERS 基板与传统金银 SERS 基板的临床性能。我们发现，如果我们采用平均灵敏度，文献中报道的临床 SERS 测定的特异性和准确性，这些参数，特别是准确性 (93–94%)，与 AgNP@Al、Si 基、Au 基和 Ag 基底物上的 SERS 生物测定相似。我们希望这篇综述能够鼓励对铝、硅和其他一些基底的 SERS 生物传感的研究。这些基于铝和硅的衬底可以有效应对 SERS 实际应用中的主要挑战。例如，与仅基于金或仅基于银的 SERS 基板相比，它们可能不仅更便宜，例如铝箔，而且在某些情况下选择性更高，有时更可重复。总的来说，它可能会导致适用的 SERS 基板更加多样化，从而可以更好地优化和选择用于特定传感/生物传感或临床应用的 SERS 基板。

"点击查看英文标题和摘要"

Trends in Application of SERS Substrates beyond Ag and Au, and Their Role in Bioanalysis

This article compares the applications of traditional gold and silver-based SERS substrates and less conventional (Pd/Pt, Cu, Al, Si-based) SERS substrates, focusing on sensing, biosensing, and clinical analysis. In recent decades plethora of new biosensing and clinical SERS applications have fueled the search for more cost-effective, scalable, and stable substrates since traditional gold and silver-based substrates are quite expensive, prone to corrosion, contamination and non-specific binding, particularly by S-containing compounds. Following that, we briefly described our experimental experience with Si and Al-based SERS substrates and systematically analyzed the literature on SERS on substrate materials such as Pd/Pt, Cu, Al, and Si. We tabulated and discussed figures of merit such as enhancement factor (EF) and limit of detection (LOD) from analytical applications of these substrates. The results of the comparison showed that Pd/Pt substrates are not practical due to their high cost; Cu-based substrates are less stable and produce lower signal enhancement. Si and Al-based substrates showed promising results, particularly in combination with gold and silver nanostructures since they could produce comparable EFs and LODs as conventional substrates. In addition, their stability and relatively low cost make them viable alternatives for gold and silver-based substrates. Finally, this review highlighted and compared the clinical performance of non-traditional SERS substrates and traditional gold and silver SERS substrates. We discovered that if we take the average sensitivity, specificity, and accuracy of clinical SERS assays reported in the literature, those parameters, particularly accuracy (93–94%), are similar for SERS bioassays on AgNP@Al, Si-based, Au-based, and Ag-based substrates. We hope that this review will encourage research into SERS biosensing on aluminum, silicon, and some other substrates. These Al and Si based substrates may respond efficiently to the major challenges to the SERS practical application. For instance, they may be not only less expensive, e.g., Al foil, but also in some cases more selective and sometimes more reproducible, when compared to gold-only or silver-only based SERS substrates. Overall, it may result in a greater diversity of applicable SERS substrates, allowing for better optimization and selection of the SERS substrate for a specific sensing/biosensing or clinical application.

更新日期：2022-11-03

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文