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Regulation and Reconstruction of Cell Phenotype Gradients Along the Tendon-Bone Interface
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2022-10-31 , DOI: 10.1002/adfm.202210275 Gao‐Peng Dang 1 , Wen Qin 1 , Qian‐Qian Wan 1 , Jun‐Ting Gu 1 , Kai‐Yan Wang 1 , Zhao Mu 1 , Bo Gao 2 , Kai Jiao 1 , Franklin R. Tay 3 , Li‐Na Niu 1
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2022-10-31 , DOI: 10.1002/adfm.202210275 Gao‐Peng Dang 1 , Wen Qin 1 , Qian‐Qian Wan 1 , Jun‐Ting Gu 1 , Kai‐Yan Wang 1 , Zhao Mu 1 , Bo Gao 2 , Kai Jiao 1 , Franklin R. Tay 3 , Li‐Na Niu 1
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Tendon–bone interface is prevalent in the human body. It is divided into four zones: tendon (soft tissue), unmineralized fibrocartilage, mineralized fibrocartilage, and bone (hard tissue). Tendon–bone interface is characterized by a cell phenotype gradient that appears in the different zones. The cell phenotype gradients at the tendon–bone interface are orchestrated by specific intracellular molecular mechanisms, extracellular factors, immune signals, and neurovascular factors. These features have inspired scientists to design systems that mimic natural cell phenotype gradients. These biomimetic systems include the construction of cell sheets, regulation of cellular microenvironments, and the design of gradient functional scaffolds. Exploration of methods to mimic cell phenotype gradients is instructional for future clinical applications in reconstituting the tendon–bone interface. The present review elucidates the gradient composition of the tendon–bone interface. The associated regulatory mechanisms and applications are discussed, with the anticipation of creating a mise en scène for future research in interface tissue engineering.
中文翻译：
肌腱-骨界面细胞表型梯度的调控与重建
肌腱-骨界面在人体中很普遍。它分为四个区域：肌腱（软组织）、未矿化的纤维软骨、矿化的纤维软骨和骨（硬组织）。肌腱-骨界面的特征在于出现在不同区域的细胞表型梯度。肌腱-骨界面的细胞表型梯度由特定的细胞内分子机制、细胞外因子、免疫信号和神经血管因子协调。这些特征激发了科学家设计模拟自然细胞表型梯度的系统。这些仿生系统包括细胞片层的构建、细胞微环境的调节以及梯度功能支架的设计。探索模拟细胞表型梯度的方法对未来重建肌腱-骨界面的临床应用具有指导意义。本综述阐明了肌腱-骨界面的梯度组成。讨论了相关的调节机制和应用，期望为界面组织工程的未来研究创造一个场景。
更新日期：2022-10-31
中文翻译：
肌腱-骨界面细胞表型梯度的调控与重建
肌腱-骨界面在人体中很普遍。它分为四个区域：肌腱（软组织）、未矿化的纤维软骨、矿化的纤维软骨和骨（硬组织）。肌腱-骨界面的特征在于出现在不同区域的细胞表型梯度。肌腱-骨界面的细胞表型梯度由特定的细胞内分子机制、细胞外因子、免疫信号和神经血管因子协调。这些特征激发了科学家设计模拟自然细胞表型梯度的系统。这些仿生系统包括细胞片层的构建、细胞微环境的调节以及梯度功能支架的设计。探索模拟细胞表型梯度的方法对未来重建肌腱-骨界面的临床应用具有指导意义。本综述阐明了肌腱-骨界面的梯度组成。讨论了相关的调节机制和应用，期望为界面组织工程的未来研究创造一个场景。
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