Cobalt(II)-Catalyzed Directed C–H Functionalization/[3+2] Annulation of N-Arylguanidines with Alkynes,Organic Letters

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Cobalt(II)-Catalyzed Directed C–H Functionalization/[3+2] Annulation of N-Arylguanidines with Alkynes
Organic Letters ( IF 4.9 ) Pub Date : 2022-10-31 , DOI: 10.1021/acs.orglett.2c02503
Harish Parihar ₁ , Natesan Thirupathi ₁

Affiliation

A family of N,N′-diaryl-N″-(quinolin-8-yl)guanidines were prepared by two methods, and these guanidines were subjected to Co(II)-catalyzed C–H functionalization/annulation with terminal and internal alkynes under mild conditions to afford a family of indole guanidines. Substrates with a range of electronic and steric properties were tolerated. The fluxional behavior of two guanidines and molecular structures of nine compounds are reported. Several key experiments were carried out to support the proposed mechanism of alkyne annulation.

中文翻译：

钴 (II) 催化的定向 C–H 官能化/[3+2] N-芳基胍与炔烃的环化

通过两种方法制备了一系列 N , N ′-二芳基-N ″-(喹啉-8-基)胍，这些胍被 Co(II) 催化的 C-H 官能化/末端和内部炔环化在温和的条件下得到一族吲哚胍。具有一系列电子和空间特性的底物是可以接受的。报道了两种胍的流动行为和九种化合物的分子结构。进行了几个关键实验来支持所提出的炔烃环化机制。

更新日期：2022-10-31

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