Galactomyces 发酵滤液增强角质形成细胞的抗炎系统,Journal of Clinical Medicine

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Galactomyces 发酵滤液增强角质形成细胞的抗炎系统
Journal of Clinical Medicine ( IF 3.0 ) Pub Date : 2022-10-27 , DOI: 10.3390/jcm11216338
Xianghong Yan ₁ , Gaku Tsuji _{2,

3} , Akiko Hashimoto-Hachiya ₃ , Masutaka Furue ₃

Affiliation

护肤品在预防各种原因引起的皮肤干燥方面起着至关重要的作用。某些成分可以帮助提高护肤品的功效。半乳糖菌属发酵滤液 (GFF) 就是这样一种功能性成分。它的使用源于经验观察，即处理酵母发酵的清酒酿酒师的手保持美丽和年轻的外观。因此，基于 GFF 的护肤品在全世界得到广泛使用。最近的研究表明，GFF 可激活芳基烃受体 (AHR) 并上调表皮角质形成细胞中聚丝蛋白的表达，丝聚蛋白是天然保湿因子的关键内源性来源。它还激活核因子红细胞 2 相关因子 2 (NRF2)，即抗氧化主转录因子，并对紫外线照射和促炎细胞因子诱导的氧化应激表现出强大的抗氧化活性，后者也会加速炎症。GFF 介导的 NRF2 激活下调 CDKN2A 的表达，已知其在衰老的角质形成细胞中过表达。此外，GFF 通过上调 caspase-14、claudin-1 和 claudin-4 的表达来增强表皮终末分化。它还促进抗炎细胞因子 IL-37 的合成，并下调角质形成细胞中促过敏细胞因子 IL-33 的表达。此外，GFF 下调了参与炎症的CXCL14和IL6R基因。这些有益的特性可能会支持含有 GFF 的皮肤配方的有效屏障保护和抗炎作用。

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Galactomyces Ferment Filtrate Potentiates an Anti-inflammaging System in Keratinocytes

Skincare products play a crucial role in preventing the dry skin induced by various causes. Certain ingredients can help to improve the efficacy of skincare products. Galactomyces ferment filtrate (GFF) is such a functional ingredient. Its use originated from the empirical observation that the hands of sake brewers who deal with yeast fermentation retain a beautiful and youthful appearance. Consequently, skincare products based on GFF are widely used throughout the world. Recent studies have demonstrated that GFF activates an aryl hydrocarbon receptor (AHR) and upregulates the expression of filaggrin, a pivotal endogenous source of natural moisturizing factors, in epidermal keratinocytes. It also activates nuclear factor erythroid-2-related factor 2 (NRF2), the antioxidative master transcription factor, and exhibits potent antioxidative activity against oxidative stress induced by ultraviolet irradiation and proinflammatory cytokines, which also accelerate inflammaging. GFF-mediated NRF2 activation downregulates the expression of CDKN2A, which is known to be overexpressed in senescent keratinocytes. Moreover, GFF enhances epidermal terminal differentiation by upregulating the expression of caspase-14, claudin-1, and claudin-4. It also promotes the synthesis of the antiinflammatory cytokine IL-37 and downregulates the expression of proallergic cytokine IL-33 in keratinocytes. In addition, GFF downregulates the expression of the CXCL14 and IL6R genes, which are involved in inflammaging. These beneficial properties might underpin the potent barrier-protecting and anti-inflammaging effects of GFF-containing skin formulae.

更新日期：2022-10-27

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