<br>PFOA 、 HFPO-DA 和 HFPO-TA 诱导的斑马鱼胚胎发育毒性比较,Chemosphere

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PFOA 、 HFPO-DA 和 HFPO-TA 诱导的斑马鱼胚胎发育毒性比较
Chemosphere ( IF 8.1 ) Pub Date : 2022-10-26 , DOI: 10.1016/j.chemosphere.2022.136999
Yonghua Wang ₁ , Shengnan Jiang ₁ , Beibei Wang ₁ , Xi Chen ₁ , Guanghua Lu ₁

Affiliation

六氟环氧丙烷二聚体酸（HFPO-DA）和六氟环氧丙烷三聚体酸（HFPO-TA）是全氟辛酸（PFOA）的替代品。然而，关于它们毒性比较的信息很少。在这里，斑马鱼胚胎暴露于暴露浓度为 5 和 500 μg/L 的 PFOA、HFPO-DA 和 HFPO-TA。测定斑马鱼胚胎中的行为异常、酶活性和基因表达谱。结果表明，暴露于 PFOA 及其替代品会增加心率并抑制斑马鱼胚胎的运动活动。此外，他们的暴露改变了酶活性（乙酰胆碱酯酶和氧化应激相关酶）、ATP 含量以及与下丘脑-垂体-甲状腺（HPT）轴、细胞凋亡和脂质代谢相关的基因表达。比较分析发现，PFOA 、 HFPO-TA 和 HFPO-DA 暴露对斑马鱼胚胎发育的影响不同，这表明作用方式不同。HFPO-DA 暴露对脂质代谢紊乱、HPT 轴和神经发育产生特异性影响。HFPO-TA 暴露还诱导了与 PFOA 暴露不同的影响，PFOA 暴露侧重于脂质代谢。目前的数据表明，HFPO-DA 和 HFPO-TA 可能不是 PFOA 的安全替代品。这项研究为水生生物中 PFOA 替代品的生物危害提供了新的理解，可以指导它们的使用。

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Comparison of developmental toxicity induced by PFOA, HFPO-DA, and HFPO-TA in zebrafish embryos

Hexafluoropropylene oxide dimer acids (HFPO-DA) and hexafluoropropylene oxide trimer acids (HFPO-TA) are alternatives to perfluorooctanoic acid (PFOA). However, little information on the comparison of their toxicities is available. Here, zebrafish embryos were exposed to PFOA, HFPO-DA, and HFPO-TA with exposure concentrations of 5 and 500 μg/L. Behavioral abnormal, enzyme activities and gene expression profiles in zebrafish embryos were determined. Results showed that exposure to PFOA and its alternatives increased heart rates and inhibited locomotor activity of zebrafish embryos. Further, their exposures changed the enzyme activities (acetylcholinesterase and oxidative stress-related enzymes), ATP content, and expressions of genes related to hypothalamic–pituitary–thyroid (HPT) axis, apoptosis, and lipid metabolism. Comparison analyses found that PFOA, HFPO-TA, and HFPO-DA exposures induced different effects on the embryonic development of zebrafish, which indicates the different modes of action. The HFPO-DA exposure induced specific effects on the disorder of lipid metabolism, HPT axis, and neurodevelopment. The HFPO-TA exposure also induced different effects from the PFOA exposure, which focused on lipid metabolism. The current data shows that the HFPO-DA and HFPO-TA might not be safe alternatives to PFOA. This study provides a new understanding of the biological hazards of PFOA alternatives in aquatic organisms, which can guide their usage.

更新日期：2022-10-26

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