Violet Phosphorus Nanosheet: A Biocompatible and Stable Platform for Stimuli-Responsive Multimodal Cancer Phototherapy,Advanced Healthcare Materials

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Violet Phosphorus Nanosheet: A Biocompatible and Stable Platform for Stimuli-Responsive Multimodal Cancer Phototherapy
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2022-10-26 , DOI: 10.1002/adhm.202201995
Chen Zhao ₁ , Xiao Han ₁ , Shanshan Wang ₁ , ZhenYi Pan ₂ , Xiaoying Tang ₁ , Zhenqi Jiang ₁

Affiliation

As a functional 2D material, black phosphorus (BP) has garnered wide attention from many researchers in recent years. BP has a wide NIR absorption window and is a promising candidate for cancer phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT). However, due to its rapid degradation and short shelf-life in conventional water, the application of BP in the field of cancer therapy is limited. Violet phosphorus (VP), the more stable allotrope of phosphorus, has not yet been investigated for its function and biological application. In this study, VP nanosheets are successfully fabricated by liquid-phase exfoliation and demonstrated that their shelf-life in deionized water could be as long as 10 days, which is much longer than that of BP. Through in vivo and in vitro experiments, the PDT, PTT, and catalytic therapeutic effects of VP, as well as its excellent biosafety for the first time are shown. VP effectively inhibits tumor growth without causing major side effects. The current study provides new ideas and strategies for the biological application of 2D sheets of phosphorus isotope and lays the foundation for further studies on exploring the biomedical application of phosphorus isotopes.

中文翻译：

紫磷纳米片：用于刺激响应多模态癌症光疗的生物相容且稳定的平台

作为一种功能性二维材料，黑磷（BP）近年来受到众多研究人员的广泛关注。BP 具有宽的 NIR 吸收窗口，是一种很有前途的癌症光疗候选药物，包括光热疗法 (PTT) 和光动力疗法 (PDT)。然而，由于其在常规水中快速降解和保质期短，BP在癌症治疗领域的应用受到限制。紫磷 (VP) 是磷的更稳定的同素异形体，其功能和生物学应用尚未得到研究。在这项研究中，VP 纳米片通过液相剥离成功制备，并证明它们在去离子水中的保质期可长达 10 天，这比 BP 的保质期长得多。通过体内外实验，PDT、PTT、首次展示了 VP 的催化治疗作用，以及其优异的生物安全性。VP 有效抑制肿瘤生长而不会引起主要副作用。本研究为二维片状磷同位素的生物学应用提供了新的思路和策略，为进一步探索磷同位素的生物医学应用奠定了基础。

更新日期：2022-10-26

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