Inspired by the Periodontium: A Universal Bacteria-Defensive Hydrogel for Preventing Percutaneous Device-Related Infection,ACS Applied Materials & Interfaces

当前位置： X-MOL 学术 › ACS Appl. Mater. Interfaces › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Inspired by the Periodontium: A Universal Bacteria-Defensive Hydrogel for Preventing Percutaneous Device-Related Infection
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-10-25 , DOI: 10.1021/acsami.2c15478
Hui Sun ₁ , Peng Yu ₁ , Xu Peng ₂ , Lingzhuang Meng ₁ , Meng Qin ₁ , Xinyuan Xu ₁ , Jianshu Li _{1,

3}

Affiliation

Percutaneous device-related infection has greatly shortened the service period of devices and seriously reduced the quality of life of patients. Bacteria are one of the main pathogenic factors and cannot be effectively and conveniently eradicated by traditional strategies (e.g., construct coatings and introduce antibiotics), due to the complex interface among medical devices, surrounding tissue, and colonizing bacteria. Inspired by the periodontium, a universal bacteria-defensive hydrogel adapting to the complicated interface is fabricated by introducing phenol-amine chemistry to a polymeric matrix of N-hydroxyethyl acrylamide (HPC hydrogels). The HPC hydrogels with excellent toughness (2.1 MJ/m³), adhesion (10.2 and 13.2 kPa for pigskin and Ti-6Al-4V alloy, respectively), and antibacterial property (up to 99.9% for both Escherichia coli and Staphylococcus aureus) contributed to the innate microbe barrier via sealing the tissue–device interface and adaptive defense to eradicate bacteria. Meanwhile, bacterial invasion experiments demonstrate HPC hydrogels possess both a bacteria-defensive property (up to 24 h) and cell-protecting function at the same time. Furthermore, the biocompatibility of HPC hydrogels is verified in tests for in vitro cytotoxicity and in vivo irritation. Hence, the designed HPC hydrogels are considered as an emerging and universal candidate for preventing bacterial infection and can protect the deep tissue around a percutaneous device.

中文翻译：

受牙周组织的启发：一种通用的细菌防御水凝胶，用于预防经皮装置相关感染

经皮器械相关感染大大缩短了器械的使用寿命，严重降低了患者的生活质量。细菌是主要致病因素之一，由于医疗器械、周围组织和定植细菌之间的复杂界面，无法通过传统策略（例如构建涂层和引入抗生素）有效且方便地根除细菌。受牙周组织的启发，通过将酚胺化学引入N-羟乙基丙烯酰胺（HPC 水凝胶）聚合物基质中，制备了一种适应复杂界面的通用细菌防御水凝胶。 HPC水凝胶具有优异的韧性（2.1 MJ/m ³ ）、附着力（猪皮和Ti-6Al-4V合金分别为10.2和13.2 kPa）和抗菌性能（对大肠杆菌和金黄色葡萄球菌均高达99.9%）通过密封组织-设备界面和适应性防御来消灭细菌，从而达到固有的微生物屏障。同时，细菌入侵实验表明HPC水凝胶同时具有细菌防御特性（长达24小时）和细胞保护功能。此外，HPC水凝胶的生物相容性在体外细胞毒性和体内刺激性测试中得到验证。因此，设计的 HPC 水凝胶被认为是预防细菌感染的新兴通用候选材料，并且可以保护经皮装置周围的深层组织。

更新日期：2022-10-25

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南