来自生物启发的聚合儿茶酚胺神经递质的介孔各向异性纳米结构及其作为光声成像剂的潜在应用,Journal of Materials Chemistry B

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来自生物启发的聚合儿茶酚胺神经递质的介孔各向异性纳米结构及其作为光声成像剂的潜在应用
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2022-10-25 , DOI: 10.1039/d2tb01756c
Zhenzhen Lu ₁ , Shahinur Acter ₁ , Boon Mian Teo ₁ , Alexis I Bishop ₂ , Rico F Tabor ₁ , Mark Louis P Vidallon ₁

Affiliation

介孔聚多巴胺 (PDA) 纳米碗可以使用 Pluronic® F-127、氨和 1,3,5-三甲基苯 (TMB) 制备，是研究最多的各向异性纳米颗粒系统之一。然而，只有有限的聚合类似物聚去甲肾上腺素（PNE）和聚肾上腺素（PEP）的报道。在此，我们首次使用 PNE 和 PEP 对最初用于制造 PDA 纳米碗的单锅软模板法进行修改，以制造新的形状各向异性纳米颗粒（介孔纳米球或“纳米高尔夫球”和纳米碗） . 这些修改包括使用不同的油相（TMB、甲苯和o-二甲苯）和氨浓度以诱导 PDA、PNE 和 PEP 颗粒的各向异性生长。此外，这项工作的特点是将形状奇特的 PDA、PNE 和 PEP 纳米粒子作为血管内光声成像增强剂应用于 Intralipid®-India 墨水基组织模拟体模中。光声成像实验表明，与其对应的介孔纳米高尔夫球和纳米聚集体相比，介孔纳米碗表现出更强的增强效果。由于单体聚合速率和所得聚合物的光吸收率不同，光声增强也遵循 PDA > PNE > PEP 的总体趋势。最后，观察到介孔纳米结构的光声信号增强了大约两到四倍，与光滑的纳米球及其纳米聚集体相比。这些结果表明，与 PDA 相比，形状操纵可以帮助克服 PNE 和 PEP 作为光声成像剂固有的较低性能。由于具有介孔和各向异性形态的纳米材料在新兴应用方面具有显着的、未开发的潜力，这些结果为未来研究基于光声活性的奇异形状 PNE 和 PEP 纳米系统奠定了基础。

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Mesoporous, anisotropic nanostructures from bioinspired polymeric catecholamine neurotransmitters and their potential application as photoacoustic imaging agents

Mesoporous polydopamine (PDA) nanobowls, which can be prepared using Pluronic® F-127, ammonia, and 1,3,5-trimethylbenzene (TMB), are one of the most studied anisotropic nanoparticle systems. However, only limited reports on polymerised analogues polynorepinephrine (PNE) and polyepinephrine (PEP) exist. Herein, we present modifications to a one-pot, soft template method, originally applied to make PDA nanobowls, to fabricate new shape-anisotropic nanoparticles (mesoporous nanospheres or “nano-golf balls” and nanobowls) using PNE and PEP for the first time. These modifications include the use of different oil phases (TMB, toluene and o-xylene) and ammonia concentrations to induce anisotropic growth of PDA, PNE, and PEP particles. Moreover, this work features the application of oddly shaped PDA, PNE, and PEP nanoparticles as intravascular photoacoustic imaging enhancers in Intralipid®–India ink-based tissue-mimicking phantoms. Photoacoustic imaging experiments showed that mesoporous nanobowls exhibit stronger enhancement, in comparison to their mesoporous nano-golf ball and nanoaggregate counterparts. The photoacoustic enhancement also followed the general trend PDA > PNE > PEP due to the differences in the rates of polymerisation of the monomers and the optical absorption of the resulting polymers. Lastly, about two- to four-fold enhancement in photoacoustic signals was observed for the mesoporous nanostructures, when compared to smooth nanospheres and their nano-aggregates. These results suggest that shape manipulation can aid in overcoming the inherently lower performance of PNE and PEP as photoacoustic imaging agents, compared to PDA. Since nanomaterials with mesoporous and anisotropic morphologies have significant, unexplored potential with emerging applications, these results set the groundwork for future studies on photoacoustically active oddly shaped PNE- and PEP-based nanosystems.

更新日期：2022-10-25

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