2-Mercapto-5-methyl-1,3,4-thiadiazole (MMTD), an important intermediate of widely used cefazolin and cefazedone antibiotics, was hardly decyclized during conventional wastewater treatment, raising a great risk to the environment. In this study, a new strategy for treating MMTD wastewater at the source by bipolar membrane electrodialysis (BMED) was proposed, realizing a material closed loop in the processes of MMTD production. Meanwhile, a laboratory-scale BMED system was set up for exploring MMTD migration, process factors, and technology implications. The results revealed that MMTD in the feed compartment may migrate into the acid/base compartment by electromigration and diffusion, the electromigration process of MMTD microspecies was controlled by its ionization, and the diffusion process of MMTD microspecies was influenced by its chemical potential on both sides of the membranes and the types of membranes. The analysis of the BMED process factors showed that these factors such as the initial pH of the feed solution, current density, flow velocity, and initial acid/base concentration affected the acid/base concentration, MMTD leakage, current efficiency, energy consumption, electric field intensity, ion flux, electrical resistance, head loss, and proton leakage. Based on these effects of the BMED process factors, some new strategies were proposed to optimize BMED process. Besides, the implications of BMED technology were affirmed by surveying the feasibility of BMED product recycling. Furthermore, this type of new strategy could be applied to the treatment of other similar wastewater at the source, realizing a closed loop in its production.

2-Mercapto-5-methyl-1,3,4-thiadiazole (MMTD) 是广泛使用的头孢唑啉和头孢西酮抗生素的重要中间体，在常规废水处理过程中几乎不脱环，给环境带来很大风险。本研究提出了一种双极膜电渗析（BMED）从源头处理MMTD废水的新策略，实现了MMTD生产过程中的材料闭环。同时，建立了实验室规模的 BMED 系统，用于探索 MMTD 迁移、工艺因素和技术影响。结果表明，进料室中的MMTD可能通过电迁移和扩散迁移到酸/碱室中，MMTD微生物的电迁移过程受其电离控制，MMTD微种的扩散过程受其在膜两侧的化学势和膜类型的影响。BMED工艺因素分析表明，原料溶液的初始pH、电流密度、流速、初始酸碱浓度等因素对酸碱浓度、MMTD泄漏、电流效率、能耗、电场强、离子通量、电阻、水头损失和质子泄漏。基于这些BMED工艺因素的影响，提出了一些优化BMED工艺的新策略。此外，通过对 BMED 产品回收的可行性进行调查，肯定了 BMED 技术的意义。此外，这种新策略可以应用于其他类似废水的源头处理，