Though the bitter global pandemic posed a severe public health threat, it set an unprecedented stage for different research teams to present various technologies for detecting SARS-CoV-2, providing a rare and hard-won lesson for one to comprehensively survey the core experimental aspects in developing pathogens electrochemical biosensors. Apart from collecting all the published biosensor studies, we focused on the effects and consequences of using different receptors, such as antibodies, aptamers, ACE 2, and MIPs, which are one of the core topics of developing a pathogen biosensor. In addition, we tried to find an appropriate and distinctive application scenario (e.g., wastewater-based epidemiology) to maximize the advantages of using electrochemical biosensors to detect pathogens. Based on the enormous amount of information from those published studies, features that fit and favor wastewater pathogen detection can be picked up and integrated into a specific strategy to perform quantitative measurements in wastewater samples.

尽管全球大流行对公众健康构成了严重威胁，但它为不同的研究团队展示了各种检测 SARS-CoV-2 的技术提供了前所未有的舞台，为全面研究核心实验方面提供了难得的来之不易的教训在开发病原体电化学生物传感器方面。除了收集所有已发表的生物传感器研究外，我们还专注于使用不同受体（如抗体、适体、ACE 2 和 MIP）的效果和后果，这是开发病原体生物传感器的核心主题之一。此外，我们试图找到一个合适且独特的应用场景（例如，基于废水的流行病学），以最大限度地发挥使用电化学生物传感器检测病原体的优势。