Dhurrin, a cyanogenic glucoside, is a plant defensive chemical synthesized from aliphatic amino acids and consists of β-d-glucopyranose linked to α-hydroxy nitrile. It is catabolized by the consecutive action of hydroxynitrilase and β-glucosidase to release hydrogen cyanide on tissue disruption during herbivory. These phytoanticipins are widely distributed across various monocot and dicot plants such as Sorghum, Macadamia, Ostrya sp., and many other plant species with ornamental, pharmaceutical, medicinal, and food value. Although repellent properties of dhurrin against herbivores are often reported, less is known about its distribution, metabolism, mode of action against insects, and application for pest control. Herein, we highlight recent updates on dhurrin distribution, biosynthesis, and catabolism along with the cyanide detoxification pathway. Additionally, this article focuses on biological activities of dhurrin against various herbivores and opportunities to explore the utilization of dhurrin as a natural pest control agent and a substitute for chemically synthesized pesticides.

Dhurrin 是一种生氰糖苷，是一种植物防御性化学物质，由脂肪族氨基酸合成，由与α -羟基腈连接的β -d-吡喃葡萄糖组成。它通过羟基腈水解酶和β-葡萄糖苷酶的连续作用分解代谢，在食草动物期间对组织破坏释放氰化氢。这些植物预期蛋白广泛分布于各种单子叶植物和双子叶植物中，例如高粱、澳洲坚果、牡蛎属。,以及许多其他具有观赏、医药、药用和食用价值的植物物种。尽管杜林蛋白对食草动物的驱避特性经常被报道，但对其分布、代谢、对昆虫的作用方式以及害虫控制的应用知之甚少。在此，我们重点介绍了杜林分布、生物合成和分解代谢以及氰化物解毒途径的最新进展。此外，本文还重点介绍了杜尔林对各种食草动物的生物活性，以及​​探索杜尔林作为天然害虫防治剂和化学合成杀虫剂替代品的利用机会。