Cost and Energy Saving Process for the Laboratory-Scale Production of Chloroform-d,Organic Process Research & Development

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Cost and Energy Saving Process for the Laboratory-Scale Production of Chloroform-d
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2022-10-21 , DOI: 10.1021/acs.oprd.2c00260
Lia Zaharani ₁ , Mohd Rafie Bin Johan ₁ , Nader Ghaffari Khaligh ₁

Affiliation

Deuterochloroform (CDCl₃), a commonly deuterated solvent in research and undergraduate laboratories and widely employed for nuclear magnetic resonance analyses, could be prepared using a more sustainable and efficient catalytic process. The synthesis includes a one-pot reaction of hexachloroacetone with deuterium oxide (D₂O) in the presence of poly(N-vinylimidazole). The catalyst is more sustainable, highly recyclable, highly chemical and thermally stable, soluble in D₂O, and high in efficiency.

中文翻译：

氯仿-d 实验室规模生产的成本和节能过程

氘代氯仿 (CDCl ₃ ) 是研究和本科实验室中常用的氘代溶剂，广泛用于核磁共振分析，可以使用更可持续、更高效的催化过程制备。该合成包括六氯丙酮与氧化氘 (D ₂ O) 在聚 ( N-乙烯基咪唑) 存在下的一锅法反应。该催化剂更可持续、高度可回收、高度化学和热稳定、可溶于D ₂ O且效率高。

更新日期：2022-10-21

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