In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent 19F NMR,Angewandte Chemie International Edition

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In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent 19F NMR
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-10-20 , DOI: 10.1002/anie.202213495
Shizhen Chen _{1,

2} , Long Xiao _{1,

2} , Yu Li _{1,

2} , Maosong Qiu _{1,

2} , Yaping Yuan _{1,

2} , Rui Zhou _{1,

2} , Conggang Li _{1,

2} , Lei Zhang _{1,

2} , Zhong-Xing Jiang _{1,

2} , Maili Liu _{1,

2} , Xin Zhou _{1,

2}

Affiliation

We report a bimodal probe to detect hypoxic tumors by both fluorescence and chemical shift dependent ¹⁹F NMR imaging under the catalysis of nitroreductase. Specifically, the concentration of nitroreductase can be detected in a broad range by fluorescence and ¹⁹F NMR, which is ≤1.5 μg mL⁻¹ and 10–50 μg mL⁻¹, respectively.

中文翻译：

通过荧光和化学位移依赖性 19F NMR 进行体内硝基还原酶成像

我们报告了一种双峰探针，可在硝基还原酶催化下通过荧光和化学位移依赖性^{19 F NMR 成像检测缺氧肿瘤。}具体而言，硝基还原酶的浓度可通过荧光和¹⁹ F NMR 在较宽的范围内检测，分别为≤1.5 μg mL ^-1和10–50 μg mL ^-1。

更新日期：2022-10-20

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