载有阿霉素的热敏脂质体固定化金纳米粒子、BP 纳米片和明胶复合支架的逐步光热疗法和化学疗法,Biomaterials Science

当前位置： X-MOL 学术 › Biomater. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

载有阿霉素的热敏脂质体固定化金纳米粒子、BP 纳米片和明胶复合支架的逐步光热疗法和化学疗法
Biomaterials Science ( IF 5.8 ) Pub Date : 2022-10-20 , DOI: 10.1039/d2bm01155g
Huajian Chen _{1,

2} , Rui Sun _{1,

2} , Tianjiao Zeng _{1,

2} , Jing Zheng _{1,

2} , Toru Yoshitomi ₁ , Naoki Kawazoe ₁ , Yingnan Yang ₃ , Guoping Chen _{1,

2}

Affiliation

近年来，光热疗法（PTT）与化疗的协同作用被认为是治疗癌症的有效策略。控制 PTT 温度和药物释放曲线对于最大限度地减少对正常细胞的意外损害是可取的。在这项研究中，通过使用可生物降解的黑磷 (BP) 纳米片、金纳米棒 (AuNRs)、阿霉素 (Dox) 封装的热敏脂质体和可生物降解聚合物的复合多孔支架，开发了逐步 PTT 和化学疗法的智能平台。在近红外 (NIR) 激光照射下，复合支架可在 BP 降解前后分别达到局部高温和低温。复合支架中的 Dox 释放可以通过温度变化来控制。体外细胞培养和体内动物实验表明，在BP降解前的治疗早期，PTT和化疗可以产生强烈的协同作用，而在BP降解后的晚期化疗表现出温和的热疗作用。此外，Dox完全释放后的复合支架可以支持间充质干细胞的增殖。复合支架显示出逐步 PTT 和化学疗法对消除乳腺癌的协同作用，并在杀死癌细胞后促进干细胞活性。

"点击查看英文标题和摘要"

Stepwise photothermal therapy and chemotherapy by composite scaffolds of gold nanoparticles, BP nanosheets and gelatin immobilized with doxorubicin-loaded thermosensitive liposomes

In recent years, the synergistic effect of photothermal therapy (PTT) and chemotherapy has been recognized as an effective strategy for cancer treatment. Controlling the PTT temperature and drug release profile is desirable for minimizing the unexpected damage to normal cells. In this study, a smart platform of stepwise PTT and chemotherapy has been developed by using composite porous scaffolds of biodegradable black phosphorus (BP) nanosheets, gold nanorods(AuNRs), doxorubicin (Dox)-encapsulated thermosensitive liposomes and biodegradable polymers. Under near-infrared (NIR) laser irradiation, the composite scaffolds could attain high and low local temperatures before and after BP degradation, respectively. Dox release from the composite scaffolds could be controlled by the temperature change. In vitro cell culture and in vivo animal experiments indicated that a strong synergistic effect of PTT and chemotherapy could be achieved at an early stage of treatment before BP degradation, and a mild hyperthermia effect was shown for chemotherapy in the late stage after BP degradation. Moreover, the composite scaffolds after the complete release of Dox could support the proliferation of mesenchymal stem cells. The composite scaffolds showed a synergistic effect of stepwise PTT and chemotherapy for breast cancer elimination and promoted stem cell activities after killing cancer cells.

更新日期：2022-10-20

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南