Metal- And Light-Free Direct C-3 Ketoalkylation of Quinoxalin-2(1H)-Ones with Cyclopropanols in Aqueous Medium,ChemistrySelect

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Metal- And Light-Free Direct C-3 Ketoalkylation of Quinoxalin-2(1H)-Ones with Cyclopropanols in Aqueous Medium
ChemistrySelect ( IF 1.9 ) Pub Date : 2022-10-19 , DOI: 10.1002/slct.202203597
Devidas A. More _{1,

2} , M. Mujahid _{1,

2} , M. Muthukrishnan _{1,

2}

Affiliation

Direct oxidative C-3 ketoalkylation of quinoxalin-2(1H)-ones with cyclopropanols using ammonium persulfate in an aqueous medium has been achieved in a moderate to good yield. The reaction does not require metals, light-source, or catalysts to facilitate the reaction and could be efficiently utilized to construct a wide range of biologically relevant 3-ketoalkylated quinoxalin-2(1H)-ones.

中文翻译：

Quinoxalin-2(1H)-One 与环丙醇在水介质中的无金属和无光直接 C-3 酮烷基化

使用过硫酸铵在水性介质中直接氧化喹喔啉-2(1 H )-酮与环丙醇的 C-3 酮烷基化反应以中等至良好的产率实现。该反应不需要金属、光源或催化剂来促进反应，并且可以有效地用于构建广泛的生物相关的 3-酮烷基化 quinoxalin-2( 1H )-ones。

更新日期：2022-10-20

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