A series of 2-(3,5-dimethylpyrazol-1-yl)ethylseleno derivatives has been synthesized. The glutathione peroxidase like catalytic activity of these compounds has been studied in a model system, in which reduction of hydrogen peroxide with dithiothreitol (DTT^red), in the presence of an organoselenium compound was investigated by ¹H NMR spectroscopy. All these compounds exhibit GPx like catalytic activities and the catalytic reaction proceeds through a selenoxide intermediate, identified by ⁷⁷Se{¹H} NMR spectroscopy.

中文翻译：

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2-（3,5-二甲基吡唑-1-基）乙基硒基衍生物及其可能的谷胱甘肽过氧化物酶（GPx）活性的合成，表征和结构†

已经合成了一系列2-（3,5-二甲基吡唑-1-基）乙基硒代衍生物。这谷胱甘肽 已在模型系统中研究了这些化合物的过氧化物酶等催化活性，其中还原了 过氧化氢 和 二硫苏糖醇通过¹ H NMR光谱研究在有机硒化合物存在下的（DTT^红）。所有这些化合物均表现出类似GPx的催化活性，并且催化反应通过亚硒酸酯中间体进行，该中间体由⁷⁷ Se { ¹ H} NMR光谱鉴定。