Platinum complex OPA shows a potent chemoimmunotherapeutic effect on tumors by impeding DNA replication and inhibiting the triggering receptor expressed on myeloid cells-2 (TREM2). OPA promotes the polarization of macrophages from immunosuppressive M2 to tumoricidal M1 phenotype, and stimulates dendritic, cytotoxic T, and natural killer cells to restrain cancer cells. By transforming the tumor microenvironment, OPA overcomes the tumor resistance to platinum drugs.

中文翻译：

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铂基 TREM2 抑制剂通过重塑免疫抑制微环境来抑制肿瘤

铂络合物 OPA 通过阻碍 DNA 复制和抑制髓样细胞 2 (TREM2) 上表达的触发受体，对肿瘤显示出有效的化学免疫治疗作用。OPA 促进巨噬细胞从免疫抑制性 M2 型向肿瘤杀伤性 M1 型的极化，并刺激树突状细胞、细胞毒性 T 细胞和自然杀伤细胞来抑制癌细胞。OPA通过改造肿瘤微环境，克服了肿瘤对铂类药物的耐药性。