抗菌生物材料表面的设计和性能,Advanced Healthcare Materials

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抗菌生物材料表面的设计和性能
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2022-10-18 , DOI: 10.1002/adhm.202202073
Babak Mehrjou ₁ , Yuzheng Wu ₁ , Pei Liu ₁ , Guomin Wang _{1,

2} , Paul K Chu ₁

Affiliation

抗生素耐药性病原体的出现已造成严重的健康问题，如果目前的趋势继续下去，由于新的抗菌素耐药性（AMR），感染的治疗将变得复杂，甚至不成功。因此，全球都在努力寻找治疗感染的新方法并开发更好的抗菌材料和疗法。尽管新的、更有效的抗生素有助于对抗微生物，但它们只能提供暂时的解决方案，因为未来的细菌菌株可能会对这些抗生素和药物产生耐药性。最近，应用非生物方法（例如电流和光热/动力疗法）来杀死细菌，揭示了设计抗菌生物材料的新方法，因为可以避免耐药细菌引起的并发症。此外，最近的研究重点是模仿植物和昆虫的表面图案，例如荷叶和蜻蜓翅膀。仿生微/纳米图案已在多种生物材料上复制，以提高细菌抵抗力和其他性能，并取得了良好的成功。这是一个令人兴奋的研究领域，具有巨大的实践和临床潜力。本文总结了应用化学/生物方法对抗细菌感染和抗菌素耐药性的最新进展，并讨论了相关机制。这是一个令人兴奋的研究领域，具有巨大的实践和临床潜力。本文总结了应用化学/生物方法对抗细菌感染和抗菌素耐药性的最新进展，并讨论了相关机制。这是一个令人兴奋的研究领域，具有巨大的实践和临床潜力。本文总结了应用化学/生物方法对抗细菌感染和抗菌素耐药性的最新进展，并讨论了相关机制。

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Design and Properties of Antimicrobial Biomaterials Surfaces

Emergence of antibiotic-resistance pathogens has caused serious health issues and if the current trend is to continue, treatment of the infection will become complicated and even unsuccessful due to new antimicrobial resistance (AMR). Therefore, there is a global drive to identify new methods to treat infection and develop better antibacterial materials and therapy. Although new and more potent antibiotics have aided the fight against microbes, they only offer a temporary solution because future bacteria strains may become resistant to these antibiotics and drugs. Recently, application of non-biological methods such as, electrical currents and photothermal/dynamic therapies to kill bacteria, reveal new approaches to design antimicrobial biomaterials, as complications stemming from drug-resistant bacteria can be obviated. Furthermore, recent research has focused on mimicking the surface patterns on plants and insects such as lotus leaves and dragonfly wings. Bio-inspired micro/nano patterns have been replicated on a variety of biomaterials to improve the bacterial resistance and other properties with good success. This is an exciting research area with immense practical and clinical potentials. In this review, recent advances in the application of chemical/biological approaches to combat bacterial infection and AMR are summarized and the related mechanisms are discussed.

更新日期：2022-10-18

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