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One-pot synthesis of 3-trifluoromethylbenzo[b][1,4]oxazines from CF3-imidoyl sulfoxonium ylides with 2-bromophenols
Chemical Communications ( IF 4.3 ) Pub Date : 2022-10-17 , DOI: 10.1039/d2cc04863a
Mingshi Pan 1 , Yixin Tong 1 , Xiaodong Qiu 1 , Xiaobao Zeng 1 , Biao Xiong 1
Chemical Communications ( IF 4.3 ) Pub Date : 2022-10-17 , DOI: 10.1039/d2cc04863a
Mingshi Pan 1 , Yixin Tong 1 , Xiaodong Qiu 1 , Xiaobao Zeng 1 , Biao Xiong 1
Affiliation
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Herein, a method to access 3-trifluoromethyl-1,4-benzoxazines from CF3-imidoyl sulfoxonium ylides and 2-bromophenols has been demonstrated. This synthetic protocol proceeds via a one-pot two-step sequence that includes the lithium-bromide-promoted O–H insertion of sulfoxonium ylides and annulation, and has the merits of broad substrate scope, excellent functional tolerance and operational simplicity, which provides an alternative means of obtaining CF3-substituted heterocycles.
中文翻译：
CF3-亚胺基亚砜叶立德与 2-溴酚一锅法合成 3-三氟甲基苯并[b][1,4]恶嗪
在此，展示了一种从 CF 3 -亚胺酰亚砜叶立德和 2-溴苯酚中获取 3-三氟甲基-1,4-苯并恶嗪的方法。该合成方案通过一锅两步序列进行，包括溴化锂促进的 O-H 插入氧化硫叶立德和环化，具有广泛的底物范围、出色的功能耐受性和操作简单性的优点，提供了获得CF 3取代的杂环的替代方法。
更新日期：2022-10-17
中文翻译：
CF3-亚胺基亚砜叶立德与 2-溴酚一锅法合成 3-三氟甲基苯并[b][1,4]恶嗪
在此，展示了一种从 CF 3 -亚胺酰亚砜叶立德和 2-溴苯酚中获取 3-三氟甲基-1,4-苯并恶嗪的方法。该合成方案通过一锅两步序列进行，包括溴化锂促进的 O-H 插入氧化硫叶立德和环化，具有广泛的底物范围、出色的功能耐受性和操作简单性的优点，提供了获得CF 3取代的杂环的替代方法。
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