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Total Synthesis of Spiro[cyclohexane-2-indoline] Alkaloids: A Regio- and Diastereoselective Spirocyclization Approach
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-10-12 , DOI: 10.1002/anie.202212042
Lu Chen 1, 2 , Kejing Xie 1 , Jingyang Zhang 1 , Liansuo Zu 1
Affiliation  

A direct spirocyclization approach was adopted for the concise chemical synthesis of a class of spiro[cyclohexane-2-indoline] alkaloids. Stereochemically complementary spirocyclic systems could be generated by manipulation of the spirocyclization pathway to favor the kinetic or thermodynamic product.

中文翻译:

螺[环己烷-2-二氢吲哚] 生物碱的全合成:区域和非对映选择性螺环化方法

采用直接螺环化方法简明化学合成一类螺[环己烷-2-二氢吲哚]生物碱。可以通过操纵螺环化途径来产生立体化学互补的螺环系统,以有利于动力学或热力学产物。
更新日期:2022-10-12
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