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Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (–)-Melearoride A and Antibiotic (–)-PF1163B
SynOpen ( IF 2.0 ) Pub Date : 2022-10-12 , DOI: 10.1055/a-1942-6969 Srihari Pabbaraja 1 , Bharath Yasam 1
中文翻译：
海洋源性抗唑类抗真菌剂 (-)-Melearoride A 和抗生素 (-)-PF1163B 的全合成
更新日期：2022-10-13
SynOpen ( IF 2.0 ) Pub Date : 2022-10-12 , DOI: 10.1055/a-1942-6969 Srihari Pabbaraja 1 , Bharath Yasam 1
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A flexible stereoselective and convergent cum divergent approach to the synthesis of two 13-membered macrolides through a common skeleton present in their structure is described featuring two different routes, with good overall yield. The key synthetic reactions utilized include Keck allylation, Evans asymmetric methylation, Grubbs metathesis, and Julia–Kocienski olefination.
中文翻译：
海洋源性抗唑类抗真菌剂 (-)-Melearoride A 和抗生素 (-)-PF1163B 的全合成
描述了一种灵活的立体选择性和收敛兼发散方法，通过其结构中存在的共同骨架合成两个 13 元大环内酯类化合物，具有两种不同的路线，具有良好的总产率。使用的关键合成反应包括 Keck 烯丙基化、Evans 不对称甲基化、Grubbs 复分解和 Julia-Kocienski 烯化。
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