Bacterial infection is a major pathological factor leading to persistent wounds. With the aging of population, wound infection has gradually become a global health-issue. The wound site environment is complicated, and the pH changes dynamically during healing. Therefore, there is an urgent need for new antibacterial materials that can adapt to a wide pH range. To achieve this goal, we developed a thymol-oligomeric tannic acid/amphiphilic sodium alginate-polylysine hydrogel film, which exhibited excellent antibacterial efficacy in the pH range from 4 to 9, achieving the highest achievable 99.993 % (4.2 log units) and 99.62 % (2.4 log units) against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, respectively. The hydrogel films exhibited excellent cytocompatibility, suggesting that the materials are promising as a novel wound healing material without the concern of biosafety.

细菌感染是导致伤口持续存在的主要病理因素。随着人口老龄化，伤口感染逐渐成为全球性的健康问题。伤口部位环境复杂，愈合过程中pH值动态变化。因此，迫切需要能够适应较宽pH范围的新型抗菌材料。为实现这一目标，我们开发了一种百里酚-低聚单宁酸/两亲性海藻酸钠-聚赖氨酸水凝胶薄膜，在 4 至 9 的 pH 范围内表现出出色的抗菌功效，最高可达到 99.993%（4.2 log 单位）和 99.62% （2.4 对数单位）对抗革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌， 分别。水凝胶薄膜表现出优异的细胞相容性，表明该材料有望成为一种无需担心生物安全性的新型伤口愈合材料。