In order to search for innovative nootropic agents, new 1-benzyl-4- (4- (R)-5-sulfonylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl) pyrrolidine-2-ones was synthesized by reacting benzylamine with itaconic acid to 1-benzyl-5-oxopyrrolidine-3-carboxylic acid, which was then subjected to hydrazinolysis followed by the addition of substituted isothiacyanate followed by cyclization of intermediate thiosemicarbazides. The structure and purity of the obtained substances were confirmed by elemental analysis, ¹H NMR spectroscopy, ¹³C NMR spectroscopy and LC/MS. Docking studies were performed for the substances synthesized using Autodock 4.2 software. Approximate values of LD₅₀ (in silico determination) are around 870–1000 mg/kg. All synthesized substances were tested for nootropic activity by the passive avoidance test on the scopolamine amnesia model in doses that are about 1/10 of the estimated LD₅₀. Based on the results of docking and pharmacological experiment, the most promising substances 7a, as well as 7e, 7f were identified. The results of molecular docking (hit compound 7a) indicate a positive correlation between the obtained values of docking studies and experimental data.

为了寻找创新的促智剂，新的 1-benzyl-4- (4- (R)-5-sulfonylidene-4,5-dihydro-1 H -1,2,4-triazol-3-yl) pyrrolidine-通过将苄胺与衣康酸反应生成 1-苄基-5-氧代吡咯烷-3-羧酸，合成 2-ones，然后将其进行肼解，然后加入取代的异硫氰酸酯，然后环化中间体氨基硫脲。^{通过元素分析、 1} H NMR光谱、¹³ C NMR光谱和LC/MS确证了所得物质的结构和纯度。使用 Autodock 4.2 软件对合成的物质进行了对接研究。_{LD 50}的近似值（计算机测定）约为 870–1000 mg/kg。所有合成物质都通过被动回避试验对东莨菪碱失忆症模型进行促智活性测试，剂量约为估计 LD ₅₀的 1/10 。根据对接和药理实验的结果，确定了最有希望的物质7a，以及7e、7f。分子对接结果（命中化合物7a）表明对接研究所得值与实验数据呈正相关。