Cognitive deficits are enduring and disabling symptoms for many patients with severe mental illness, and these impairments are inadequately addressed by current medications. In this study, we reported the synthesis of β-arylchalcogeno amines bearing sulfurated, selenated, and tellurated moieties (2–4) which are structurally related to amphetamine with good activation properties for Carbonic Anhydrases (CAs) isoforms present in the cortical and hippocampal brain structures (hCA IV and hCA XIV). In addition, these compounds showed selective inhibition against the Monoamine oxidase (MAO) A isoform. In vivo evaluation of two derivatives (2a and 3a) revealed procognitive effects in the object recognition and social discrimination tests. Interestingly, these compounds, despite having a similar structure to amphetamine, did not caused hypophagia or hyperlocomotion, two effects often observed following the administration of amphetamine-like drugs. In this context, β-arylchalcogeno amines may have utility for improving the symptoms of cognitive decline associated with neurodegenerative and psychiatric diseases such as attention deficit disorder, Parkinson's disease-related cognitive dysfunction and cognitive disorders associated with depression.

对于许多患有严重精神疾病的患者来说，认知缺陷是持久的和致残的症状，而目前的药物治疗不足以解决这些障碍。在这项研究中，我们报道了带有硫化、硒化和碲化部分 ( 2–4 )的 β-芳基硫族胺的合成，这些部分在结构上与苯丙胺相关，对存在于皮质和海马脑中的碳酸酐酶 (CA) 亚型具有良好的活化特性结构（hCA IV 和 hCA XIV）。此外，这些化合物对单胺氧化酶 (MAO) A 亚型表现出选择性抑制作用。两种衍生物的体内评价（2a和3a) 在对象识别和社会歧视测试中揭示了前认知效应。有趣的是，这些化合物尽管与苯丙胺具有相似的结构，但不会引起吞咽不足或过度运动，这两种效应在服用苯丙胺类药物后经常观察到。在这种情况下，β-芳基硫族胺可能有助于改善与神经退行性和精神疾病相关的认知衰退症状，例如注意力缺陷障碍、帕金森病相关的认知功能障碍和与抑郁症相关的认知障碍。