<br>将软骨细胞的生物力学微环境工程化为关节软骨组织工程,Life Sciences

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将软骨细胞的生物力学微环境工程化为关节软骨组织工程
Life Sciences ( IF 5.2 ) Pub Date : 2022-10-04 , DOI: 10.1016/j.lfs.2022.121043
Weichang Xu ₁ , Jing Zhu ₁ , Jiawei Hu ₁ , Lin Xiao ₁

Affiliation

组织工程在生产用于软骨损伤修复和置换的软骨类似物方面具有很大的前景。然而，长期以来，关节软骨组织工程中关于免疫原性、稳定性和机械强度等的各种问题仍未解决。最显着的原因之一在于关节软骨组织工程中缺乏或不充分概括软骨细胞生物力学微环境（BME）。近年来，越来越多的研究揭示了 BME 在软骨细胞表型和软骨功能中的关键作用，这激发了通过工程化软骨细胞 BME 对关节软骨组织工程进行更精确和个体化的研究。本综述首先深入研究了软骨细胞 BME 及其对软骨细胞和关节软骨组织的关键影响。然后，作为这项工作的核心，从模拟软骨细胞 BME 的主要特征（包括异质基质工程和动态机械刺激）的角度，全面讨论了将软骨细胞 BME 工程化为关节软骨组织工程的主要策略及其方法。还提出了这一新兴领域的当前局限性和潜在策略，以阐明该领域的未来方向。尽管获得具有所需性能的工程关节软骨仍然存在挑战，但在不断努力将更高级别的软骨细胞 BME 工程化为关节软骨组织工程的情况下，前方的道路是光明的。

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Engineering the biomechanical microenvironment of chondrocytes towards articular cartilage tissue engineering

Tissue engineering holds great promise in the generation of cartilage analogues for cartilage injury repair and replacement. However, for a long time, a variety of issues have remained unsolved in articular cartilage tissue engineering concerning immunogenicity, stability, and mechanical strength, among others. One of the most remarkable reasons lies in the lack or insufficiency of recapitulating the chondrocyte biomechanical microenvironment (BME) in the articular cartilage tissue engineering. In recent years, an increasing number of studies have disclosed the crucial role of the BME in chondrocyte phenotype and cartilage functions, which has inspired more precise and individualized research in articular cartilage tissue engineering by engineering the chondrocyte BME. This review first takes an in-depth look into the chondrocyte BME and its crucial effects on chondrocytes and articular cartilage tissues. Then, as the core of this work, the principal strategies and their approaches of engineering the chondrocyte BME towards articular cartilage tissue engineering were comprehensively discussed, from the perspectives of simulating the main characteristics of chondrocyte BME including engineering the heterogeneous matrix and the dynamic mechanical stimulation. The current limitations in this emerging area and potential strategies were also proposed to shed some light on the future directions in this field. Although there are still challenges to obtaining engineered articular cartilages with desired performance, the road ahead is bright under the constant efforts in engineering the chondrocyte BME at higher levels towards articular cartilage tissue engineering.

更新日期：2022-10-04

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