Expanded Sequence Space of Radical S-Adenosylmethionine-Dependent Enzymes Involved in Post-translational Macrocyclization**,Angewandte Chemie International Edition

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Expanded Sequence Space of Radical S-Adenosylmethionine-Dependent Enzymes Involved in Post-translational Macrocyclization**
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-10-05 , DOI: 10.1002/anie.202212447
Bei-Bei He _{1,

2} , Zhuo Cheng ₁ , Zheng Zhong ₁ , Ying Gao _{1,

2} , Hongyan Liu _{1,

2} , Yong-Xin Li _{1,

2}

Affiliation

The rSAM enzymes are known to catalyze diverse crosslink formation in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs). Here, we develop a small peptide and enzyme co-occurrence analysis workflow (SPECO) to reveal the untapped biosynthetic landscape of rSAM-modified RiPPs and characterize cyclophane-forming enzymes that catalyze various tyrosine/histidine-aliphatic side chain crosslinks.

中文翻译：

参与翻译后大环化的自由基 S-腺苷甲硫氨酸依赖性酶的扩展序列空间**

已知 rSAM 酶在核糖体合成和翻译后修饰的肽 (RiPP) 的生物合成中催化不同的交联形成。在这里，我们开发了一个小肽和酶共现分析工作流程 (SPECO)，以揭示 rSAM 修饰的 RiPP 尚未开发的生物合成景观，并表征催化各种酪氨酸/组氨酸-脂肪族侧链交联的环状烷形成酶。

更新日期：2022-10-05

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