Synthesis of Axially Chiral Biaryls via Enantioselective Ullmann Coupling of ortho-Chlorinated Aryl Aldehydes Enabled by a Chiral 2,2′-Bipyridine Ligand,Angewandte Chemie International Edition

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Synthesis of Axially Chiral Biaryls via Enantioselective Ullmann Coupling of ortho-Chlorinated Aryl Aldehydes Enabled by a Chiral 2,2′-Bipyridine Ligand
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-10-04 , DOI: 10.1002/anie.202212108
Saima Perveen ₁ , Shuai Zhang ₂ , Linghua Wang ₂ , Peidong Song ₂ , Yizhao Ouyang ₂ , Jiao Jiao ₁ , Xin-Hua Duan ₁ , Pengfei Li _{1,

2,

3}

Affiliation

Reported is a general and highly enantioselective Ni-catalyzed reductive homocoupling of ortho-chlorinated aldehydes enabled by a SBpy-type chiral 2,2′-bipyridine ligand. This mild and step-economical approach allowed the synthesis of various axially chiral biaryl dials, and also provided versatile intermediates for diverse axially chiral catalysts, ligands, and natural products.

中文翻译：

通过手性 2,2'-联吡啶配体实现的邻氯代芳基醛的对映选择性 Ullmann 偶联合成轴向手性联芳基化合物

报道了由 SBpy 型手性 2,2'-联吡啶配体实现的一般且高度对映选择性的 Ni 催化的邻氯代醛的还原自偶联。这种温和且步骤经济的方法允许合成各种轴向手性联芳基表盘，并为各种轴向手性催化剂、配体和天然产物提供多功能中间体。

更新日期：2022-10-04

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