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A Biocompatible Self-Powered Piezoelectric Poly(vinyl alcohol)-Based Hydrogel for Diabetic Wound Repair
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-10-04 , DOI: 10.1021/acsami.2c13026 Limin Wang 1 , Yaru Yu 2 , Xiaowen Zhao 2 , Zhen Zhang 1 , Xueling Yuan 1 , Jinlong Cao 2 , Weikun Meng 1 , Lin Ye 2 , Wei Lin 3 , Guanglin Wang 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-10-04 , DOI: 10.1021/acsami.2c13026 Limin Wang 1 , Yaru Yu 2 , Xiaowen Zhao 2 , Zhen Zhang 1 , Xueling Yuan 1 , Jinlong Cao 2 , Weikun Meng 1 , Lin Ye 2 , Wei Lin 3 , Guanglin Wang 1
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Acute and chronic wounds, caused by trauma, tumors, diabetic foot ulcers, etc., are usually difficult to heal, while applying exogenous electrical stimulation to enhance the endogenous electric field in the wound has been proven to significantly accelerate wound healing. However, traditional electrical stimulation devices require an additional external power supply, making them poor in portability and comfort. In this work, a self-powered piezoelectric poly(vinyl alcohol) (PVA)/polyvinylidene fluoride (PVDF) composite hydrogel is constructed by establishing a distinctive preparation process of freezing/thawing-solvent replacement-annealing-swelling. The hydrogen bonding in the hydrogel is remarkably enhanced by the annealing-swelling process, which is stronger between PVA/PVDF molecules than that between PVA molecules, promoting transformation of the α-phase into the electroactive β-phase PVDF and facilitating formation of a much more crystalline structure with high cross-linking density. Hence, an obvious piezoelectric response with high piezoelectric coefficient and electrical signal output with superior stability and sensitivity and excellent mechanical strength and stretchability was achieved for hydrogels. PVA/PVDF composite hydrogels with good cytocompatibility significantly promote proliferation, migration, and secretion of extracellular matrix proteins and growth factors of fibroblasts, possibly through activating the AKT and ERK1/2 signaling pathways. In a wound model of diabetic rats, piezoelectric hydrogels could not only rapidly attract wound exudate and maintain the wet environment of the wound bed but also convert the mechanical energy generated by rats’ physical activities into electrical energy, so as to provide local piezoelectric stimulation to the wound bed evenly and symmetrically in real time. Such an effect significantly promotes re-epithelialization and collagen deposition and increases angiogenesis and secretion of growth factors in wound tissue. Besides, it regulates the macrophage phenotype from the M1 subtype (pro-inflammatory subtype) to the M2 subtype (anti-inflammatory subtype) and reduces the expression levels of inflammatory factors, thus accelerating wound healing. The development of such a novel piezoelectric hydrogel provides new therapeutic strategies for chronic wound healing.
中文翻译：
用于糖尿病伤口修复的生物相容性自供电压电聚（乙烯醇）基水凝胶
由外伤、肿瘤、糖尿病足溃疡等引起的急慢性伤口通常难以愈合，而应用外源性电刺激增强伤口内源性电场已被证明能显着加速伤口愈合。然而，传统的电刺激设备需要额外的外部电源，使其便携性和舒适性较差。在这项工作中，通过建立独特的冷冻/解冻-溶剂置换-退火-溶胀制备工艺，构建了一种自供电压电聚（乙烯醇）（PVA）/聚偏二氟乙烯（PVDF）复合水凝胶。水凝胶中的氢键通过退火-溶胀过程显着增强，PVA/PVDF分子之间的氢键比PVA分子之间的强，促进α相转变为电活性β相PVDF，并促进形成具有高交联密度的结晶结构。因此，水凝胶获得了具有高压电系数和电信号输出的明显压电响应，具有优异的稳定性和灵敏度以及优异的机械强度和拉伸性。具有良好细胞相容性的 PVA/PVDF 复合水凝胶显着促进细胞外基质蛋白和成纤维细胞生长因子的增殖、迁移和分泌，可能通过激活 AKT 和 ERK1/2 信号通路。在糖尿病大鼠的伤口模型中，压电水凝胶不仅能快速吸引创面渗液，维持创面湿润环境，还能将大鼠体力活动产生的机械能转化为电能，为创面提供均匀对称的局部压电刺激。时间。这种作用显着促进了上皮再形成和胶原蛋白沉积，并增加了伤口组织中的血管生成和生长因子的分泌。此外，它还调节巨噬细胞表型从M1亚型（促炎亚型）到M2亚型（抗炎亚型），降低炎症因子的表达水平，从而加速伤口愈合。这种新型压电水凝胶的开发为慢性伤口愈合提供了新的治疗策略。
更新日期：2022-10-04
中文翻译：
用于糖尿病伤口修复的生物相容性自供电压电聚（乙烯醇）基水凝胶
由外伤、肿瘤、糖尿病足溃疡等引起的急慢性伤口通常难以愈合，而应用外源性电刺激增强伤口内源性电场已被证明能显着加速伤口愈合。然而，传统的电刺激设备需要额外的外部电源，使其便携性和舒适性较差。在这项工作中，通过建立独特的冷冻/解冻-溶剂置换-退火-溶胀制备工艺，构建了一种自供电压电聚（乙烯醇）（PVA）/聚偏二氟乙烯（PVDF）复合水凝胶。水凝胶中的氢键通过退火-溶胀过程显着增强，PVA/PVDF分子之间的氢键比PVA分子之间的强，促进α相转变为电活性β相PVDF，并促进形成具有高交联密度的结晶结构。因此，水凝胶获得了具有高压电系数和电信号输出的明显压电响应，具有优异的稳定性和灵敏度以及优异的机械强度和拉伸性。具有良好细胞相容性的 PVA/PVDF 复合水凝胶显着促进细胞外基质蛋白和成纤维细胞生长因子的增殖、迁移和分泌，可能通过激活 AKT 和 ERK1/2 信号通路。在糖尿病大鼠的伤口模型中，压电水凝胶不仅能快速吸引创面渗液，维持创面湿润环境，还能将大鼠体力活动产生的机械能转化为电能，为创面提供均匀对称的局部压电刺激。时间。这种作用显着促进了上皮再形成和胶原蛋白沉积，并增加了伤口组织中的血管生成和生长因子的分泌。此外，它还调节巨噬细胞表型从M1亚型（促炎亚型）到M2亚型（抗炎亚型），降低炎症因子的表达水平，从而加速伤口愈合。这种新型压电水凝胶的开发为慢性伤口愈合提供了新的治疗策略。
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