MIL-53(Fe)衍生的蚁巢结构多孔碳纳米球CuFeS2/C用于测定阿托品对映体杂质L-天仙子胺,Chirality

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MIL-53(Fe)衍生的蚁巢结构多孔碳纳米球CuFeS2/C用于测定阿托品对映体杂质L-天仙子胺
Chirality ( IF 2.8 ) Pub Date : 2022-10-03 , DOI: 10.1002/chir.23500
Jiashuai Zhu ₁ , Kang Li ₁

Affiliation

在这项工作中，开发了一种蚁巢结构的多孔碳纳米球，用于识别检测阿托品 (ATP) 对映异构体 D-hyoscyamine (D-HSM) 和 L-hyoscyamine (L-HSM)。首先，以铁基有机骨架为底物，分别引入Cu离子和硫离子，通过水热孵育得到具有蚁巢结构的CuFeS _{2 。}然后通过高温煅烧获得CuFeS _{2 /C多孔纳米球(PNSs)。}_{由于 CuFeS 2}的协同作用，复合修饰电极对 L-HSM 表现出优异的电化学性能立方晶体和多孔碳，具有高比表面积的蚁巢结构。此外，通过循环伏安法与磺化-β-环糊精（S-β-CD）和L-精氨酸（L-Arg）形成的关于L-HSM的分子印迹聚合物（MIP）显示出对D / L-HSM的强烈手性识别（ATP）。因此，基于CuFeS ₂ /C PNSs和MIP构建了一种新型电化学传感器，通过差分脉冲伏安法检测L-HSM。在最佳条件下，L-HSM 的峰电流密度在 0.02–4.6 μM 的浓度范围内呈良好的线性关系，LOD 和 LOQ 分别为 0.45 和 1.5 nM。从外消旋ATP中成功鉴定出L-HSM和D-HSM的氧化峰，氧化峰电位差（ΔE _p) 之间为0.138 V。综上所述，该传感器具有良好的重现性、重复性和稳定性，已应用于人血清、唾液和ATP硫酸盐片中L-HSM的测定，结果令人满意。

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MIL-53(Fe)-derived ant nest structured porous carbon nanospheres CuFeS2/C for the determination of atropine enantiomeric impurity L-hyoscyamine

In this work, an ant nest structured porous carbon nanosphere had been developed for the recognition detection of the atropine (ATP) enantiomers D-hyoscyamine (D-HSM) and L-hyoscyamine (L-HSM). Firstly, Fe-based organic framework was used as the substrate, and Cu ions and sulfur ions were separately introduced to obtain CuFeS₂ with ant nest structure by hydrothermal incubation. Then CuFeS₂/C porous nanospheres (PNSs) were obtained by high-temperature calcination. The composite-modified electrode exhibited superior electrochemical performance for L-HSM due to the synergistic effect of CuFeS₂ cubic crystals and porous carbon, which has the high specific surface area of the ant nest structure. In addition, the molecularly imprinted polymer (MIP) about L-HSM formed with sulfonated-β-cyclodextrin (S-β-CD) and L-arginine (L-Arg) by cyclic voltammetry showed strong chiral recognition of D/L-HSM (ATP). Therefore, a novel electrochemical sensor was constructed based on CuFeS₂/C PNSs and MIP to detect L-HSM by differential pulse voltammetry. Under the optimal conditions, the peak current density of L-HSM showed a good linearity in the concentration range of 0.02–4.6 μM with LOD and LOQ of 0.45 and 1.5 nM, respectively. The oxidation peaks of L-HSM and D-HSM were successfully identified from the racemic ATP, and the oxidation peak potential difference (ΔE_p) between them was 0.138 V. In conclusion, the sensor showed excellent reproducibility, repeatability, and stability and had been applied to the determination of L-HSM in human serum, saliva, and ATP sulfate tablets with satisfactory results.

更新日期：2022-10-03

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