椎间盘修复策略及生物活性功能材料,Advanced Functional Materials

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椎间盘修复策略及生物活性功能材料
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2022-10-04 , DOI: 10.1002/adfm.202209471
Di Wu ₁ , Gaocai Li ₁ , Xingyu Zhou ₁ , Weifeng Zhang ₁ , Huaizhen Liang ₁ , Rongjin Luo ₁ , Kun Wang ₁ , Xiaobo Feng ₁ , Yu Song ₁ , Cao Yang ₁

Affiliation

椎间盘 (IVD) 退变是腰痛的主要原因，这是一种非常普遍的慢性衰老相关疾病，具有巨大的社会经济负担和生活质量的大幅下降，导致对 IVD 治疗的迫切需求. 因此，寻找有效的疾病缓解方法来延缓 IVD 退变的进展和修复退变的椎间盘非常重要，甚至面临各种具有挑战性的障碍。生物活性功能材料在调节细胞活性和重塑组织稳态方面表现出卓越的进步，可作为组织修复和器官重建的一种有前途且易于使用的治疗方法。最近，这些已被显着探索以研究基于生物活性功能材料的椎间盘恢复和再生修复策略，包括基于细胞的组织工程、椎间盘恢复植入物的开发以及重塑 IVD 功能完整性的治疗方法。本文综述了生物活性功能材料在IVD修复和再生方面的最新进展，并讨论了它们的调控机制、局限性、挑战以及未来的临床转化前景。

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Repair Strategies and Bioactive Functional Materials for Intervertebral Disc

Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which represents a highly prevalent chronic aging-associated disorder with a large socio-economic burden and a great decline in the quality of life, contributing to the pressing need for IVD treatments. Thus, finding effective disease-modifying approaches for postponing the progression of IVD degeneration and repairing degenerated intervertebral discs is of great importance, even facing various challengeable obstacles. Bioactive functional materials exhibit excellent advances in modulating cell activity and remodeling tissue homeostasis, which acts as a promising and accessible therapeutic approach to tissue repair and organ reconstruction. Recently, these have been notably explored to investigate bioactive functional materials-based repair strategies for intervertebral disc recovery and regeneration, including cell-based tissue engineering, the development of implants for disc recovery, and therapeutic methods for remodeling the functional integrity of the IVD. This review summarizes the advanced progress of bioactive functional materials in IVD repair and regeneration, and discusses their regulatory mechanisms, limitations, challenges as well as their clinical translational prospects in the future.

更新日期：2022-10-04

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