A mechanically robust and stable estradiol-loaded PHEMA-based hydrogel barrier for intrauterine adhesion treatment,Journal of Materials Chemistry B

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A mechanically robust and stable estradiol-loaded PHEMA-based hydrogel barrier for intrauterine adhesion treatment
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2022-10-04 , DOI: 10.1039/d2tb01740g
Xiangyan Xie ₁ , Ruijuan Xu ₂ , Hongyan Ouyang ₁ , Shiqiao Tan ₂ , Chuan Guo ₃ , Xingqi Luo ₁ , Yuanjie Xie ₁ , Di Wu ₁ , Xiangyu Dong ₄ , Jinrong Wu ₄ , Yi Wang _{1,

4} , Lijuan Zhao ₁

Affiliation

Estrogen combined with physical barrier therapy may be a prospective method to repair a damaged endometrium and prevent postsurgical re-adhesion in the treatment of intrauterine adhesions (IUAs), but there lacks a suitable scaffold with good biocompatibility, appropriate mechanical properties, and drug-releasing kinetics. Herein, a mechanically robust and stable barrier based on the poly(hydroxyethyl methacrylate) (PHEMA) hydrogel combined with estradiol-loaded mesoporous silica is designed. The network is formed by covalent bonds and noncovalent coordination bonds, which endow the hydrogel with superior mechanical properties to most reported PHEMA-based hydrogels. Meanwhile, the covalent bonds impart excellent stability to the hydrogel, which maintains its structure and mechanical properties in a simulated uterine fluid for 30 days. The excellent mechanical properties and stability are comparable to those of a typical barrier material intrauterine device (IUD), enabling the hydrogel to be retained in the uterus and removed intact like an IUD. In vitro and in vivo experiments show that the hydrogel possesses good biocompatibility similar to pure PHEMA hydrogels. In addition, the hydrogel releases estradiol continuously and stably, and exhibits a good therapeutic effect in promoting the proliferation of endometrial cells and inhibiting the progression of fibrosis. Therefore, the combinational advantages make the present hydrogel very promising in IUA treatment.

中文翻译：

用于宫腔粘连治疗的机械坚固且稳定的负载雌二醇的基于 PHEMA 的水凝胶屏障

雌激素联合物理屏障治疗宫腔粘连（IUAs）可能是修复受损子宫内膜和预防术后再粘连的一种前瞻性方法，但目前缺乏生物相容性好、机械性能适宜、药物释放良好的支架动力学。在此，设计了一种基于聚（甲基丙烯酸羟乙酯）（PHEMA）水凝胶与负载雌二醇的介孔二氧化硅结合的机械坚固且稳定的屏障。该网络由共价键和非共价配位键形成，赋予水凝胶优于大多数报道的基于 PHEMA 的水凝胶的机械性能。同时，共价键赋予水凝胶出色的稳定性，使其在模拟子宫液中保持其结构和机械性能 30 天。体外和体内实验表明，该水凝胶具有与纯 PHEMA 水凝胶相似的良好生物相容性。此外，该水凝胶持续稳定释放雌二醇，在促进子宫内膜细胞增殖、抑制纤维化进展方面表现出良好的治疗作用。因此，综合优势使本水凝胶在 IUA 治疗中非常有前途。

更新日期：2022-10-04

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