多囊卵巢综合征患者血清miR-222-3p与糖脂代谢的相关性研究,BMC Women's Health

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多囊卵巢综合征患者血清miR-222-3p与糖脂代谢的相关性研究
BMC Women's Health Pub Date : 2022-10-01 , DOI: 10.1186/s12905-022-01912-w
Qin Wang ₁ , Chuanxiang Fang ₁ , Ying Zhao ₁ , Zhaoxia Liu ₁

Affiliation

microRNA (miRNA) 在多囊卵巢综合征 (PCOS) 中发挥着关键作用，PCOS 是一种常见于育龄妇女的内分泌和代谢疾病。本文旨在检测PCOS患者血清中miR-222-3p的表达，探讨其在PCOS诊断及糖尿病及心血管并发症预测中的临床价值。共招募 PCOS 患者 111 名和健康人 94 名，分配到超重（ow）组和非超重（non-ow）组，然后测定血清 miR-222-3p 表达。分析了miR-222-3p对PCOS ow和non-ow患者的诊断效率。分析了 miR-222-3p 和糖脂代谢指标与 PCOS 中糖尿病和心血管并发症的相关性。预测了miR-222-3p的下游靶点并验证了它们的结合关系。分析PGC-1α与miR-222-3p之间的相关性。miR-222-3p 在 PCOS 患者中高度表达（p < 0.001），尤其是 PCOS 患者。miR-222-3p 诊断 PCOS non-ow 患者的曲线下面积 (AUC) 为 0.9474，临界值为 1.290（敏感性 89.06%，特异性 98.11%），表明血清 miR-222 的 non-ow 人-3p > 1.290 基本可以诊断为PCOS。miR-222-3p诊断PCOS ow患者的AUC为0.9647，临界值为2.425（敏感性85.11%，特异性100%），提示血清miR-222-3p>2.425的ow人基本可以诊断为PCOS。miR-222-3p 与空腹血糖 (FPG)、空腹胰岛素 (FINS)、稳态模型评估 - 胰岛素抵抗 (HOMA-IR) 和低密度脂蛋白胆固醇 (LDL-C) 并与高密度脂蛋白胆固醇 (HDL-C) 负相关。miR-222-3p 与 PCOS 中的糖尿病和心血管并发症独立相关（p < 0.05）。miR-222-3p 的高表达预示着 PCOS 中糖尿病和心血管并发症的高风险。miR-222-3p 靶向 PGC-1α 并与 PGC-1α 负相关（r = - 0.2851，p = 0.0224；r = - 0.3151，p = 0.0310）。miR-222-3p 的高表达有助于 PCOS 的诊断并预测糖尿病和心血管并发症的风险增加。miR-222-3p 靶向 PGC-1α 并与 PGC-1α 负相关。和低密度脂蛋白胆固醇（LDL-C）并与高密度脂蛋白胆固醇（HDL-C）负相关。miR-222-3p 与 PCOS 中的糖尿病和心血管并发症独立相关（p < 0.05）。miR-222-3p 的高表达预示着 PCOS 中糖尿病和心血管并发症的高风险。miR-222-3p 靶向 PGC-1α 并与 PGC-1α 负相关（r = - 0.2851，p = 0.0224；r = - 0.3151，p = 0.0310）。miR-222-3p 的高表达有助于 PCOS 的诊断并预测糖尿病和心血管并发症的风险增加。miR-222-3p 靶向 PGC-1α 并与 PGC-1α 负相关。和低密度脂蛋白胆固醇（LDL-C）并与高密度脂蛋白胆固醇（HDL-C）负相关。miR-222-3p 与 PCOS 中的糖尿病和心血管并发症独立相关（p < 0.05）。miR-222-3p 的高表达预示着 PCOS 中糖尿病和心血管并发症的高风险。miR-222-3p 靶向 PGC-1α 并与 PGC-1α 负相关（r = - 0.2851，p = 0.0224；r = - 0.3151，p = 0.0310）。miR-222-3p 的高表达有助于 PCOS 的诊断并预测糖尿病和心血管并发症的风险增加。miR-222-3p 靶向 PGC-1α 并与 PGC-1α 负相关。miR-222-3p 的高表达预示着 PCOS 中糖尿病和心血管并发症的高风险。miR-222-3p 靶向 PGC-1α 并与 PGC-1α 负相关（r = - 0.2851，p = 0.0224；r = - 0.3151，p = 0.0310）。miR-222-3p 的高表达有助于 PCOS 的诊断并预测糖尿病和心血管并发症的风险增加。miR-222-3p 靶向 PGC-1α 并与 PGC-1α 负相关。miR-222-3p 的高表达预示着 PCOS 中糖尿病和心血管并发症的高风险。miR-222-3p 靶向 PGC-1α 并与 PGC-1α 负相关（r = - 0.2851，p = 0.0224；r = - 0.3151，p = 0.0310）。miR-222-3p 的高表达有助于 PCOS 的诊断并预测糖尿病和心血管并发症的风险增加。miR-222-3p 靶向 PGC-1α 并与 PGC-1α 负相关。

"点击查看英文标题和摘要"

Correlation study on serum miR-222-3p and glucose and lipid metabolism in patients with polycystic ovary syndrome

microRNAs (miRNAs) play pivotal roles in polycystic ovary syndrome (PCOS), an endocrine and metabolic disorder that commonly occurs in women of childbearing age. This paper aimed to measure miR-222-3p expression in sera of PCOS patients and to explore its clinical value on PCOS diagnosis and prediction of diabetic and cardiovascular complications. Totally 111 PCOS patients and 94 healthy people were recruited and assigned to the overweight (ow) group and non-overweight (non-ow) group, followed by determination of serum miR-222-3p expression. The diagnostic efficiency of miR-222-3p on PCOS ow and non-ow patients was analyzed. Correlations between miR-222-3p and glycolipid metabolic indicators and diabetic and cardiovascular complications in PCOS were analyzed. The downstream target of miR-222-3p was predicted and their binding relationship was verified. The correlation between PGC-1α and miR-222-3p was analyzed. miR-222-3p was highly-expressed in PCOS patients (p < 0.001), in especially PCOS ow patients. The area under the curve (AUC) of miR-222-3p diagnosing PCOS non-ow patients was 0.9474 and cut-off value was 1.290 (89.06% sensitivity, 98.11% specificity), indicating that non-ow people with serum miR-222-3p > 1.290 could basically be diagnosed with PCOS. AUC of miR-222-3p diagnosing PCOS ow patients was 0.9647 and cut-off value was 2.425 (85.11% sensitivity, 100% specificity), suggesting that ow people with serum miR-222-3p > 2.425 could basically be diagnosed with PCOS. miR-222-3p was positively-correlated with fasting plasma glucose (FPG), fasting insulin (FINS), homeostatic model assessment–insulin resistance (HOMA-IR), and low-density lipoprotein cholesterol (LDL-C) and negatively-correlated with high-density lipoprotein cholesterol (HDL-C). miR-222-3p was independently-correlated with diabetic and cardiovascular complications in PCOS (p < 0.05). High expression of miR-222-3p predicted high risks of diabetic and cardiovascular complications in PCOS. miR-222-3p targeted PGC-1α and was negatively-correlated with PGC-1α (r = − 0.2851, p = 0.0224; r = − 0.3151, p = 0.0310). High expression of miR-222-3p assisted PCOS diagnosis and predicted increased risks of diabetic and cardiovascular complications. miR-222-3p targeted PGC-1α and was negatively-correlated with PGC-1α.

更新日期：2022-10-01

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