Iridium-Catalyzed Asymmetric Allylic Benzylation with Photogenerated Hydroxy-o-Quinodimethanes,Angewandte Chemie International Edition

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Iridium-Catalyzed Asymmetric Allylic Benzylation with Photogenerated Hydroxy-o-Quinodimethanes
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-09-30 , DOI: 10.1002/anie.202213520
Pusu Yang ₁ , Rui-Xiang Wang ₁ , Yuan-Zheng Cheng ₁ , Chao Zheng ₁ , Shu-Li You ₁

Affiliation

An iridium-catalyzed asymmetric allylic benzylation with 2-methylbenzophenone derivatives under light irradiation is described. The corresponding nucleophilic photoenols generated under light irradiation, enabled the reaction to take place in reasonable yields (up to 77 %) and excellent enantioselectivity (up to 99 % ee). The reaction proceeds under mild conditions, without the need for strong bases, or pre-decoration of the substrates.

中文翻译：

铱催化的不对称烯丙基苄基化与光生羟基-邻-喹啉二甲烷

描述了在光照射下用 2-甲基二苯甲酮衍生物进行的铱催化的不对称烯丙基苄基化反应。在光照射下产生相应的亲核光烯醇，使反应能够以合理的产率（高达 77%）和出色的对映选择性（高达 99% ee）进行。反应在温和的条件下进行，不需要强碱，也不需要对底物进行预修饰。

更新日期：2022-09-30

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