Thermoresponsive and antibacterial two-dimensional polyglycerol-interlocked-polynipam for targeted drug delivery,Journal of Nanostructure in Chemistry

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Thermoresponsive and antibacterial two-dimensional polyglycerol-interlocked-polynipam for targeted drug delivery
Journal of Nanostructure in Chemistry ( IF 8.6 ) Pub Date : 2022-09-30 , DOI: 10.1007/s40097-022-00514-0
Nasim Khosravani ₁ , Vahid Ahmadi ₂ , Ali Kakanejadifard ₁ , Mohsen Adeli ₁

Affiliation

Two-dimensional polymeric networks are a new class of polymers with interesting physicochemical and biological properties. They promise a wide range of future biomedical applications including pathogen interactions, drug delivery, bioimaging, photothermal, and photodynamic therapy, owing to their unique features, such as high surface area and multivalent interactions at nano-biointerfaces. In this work, a thermosensitive two-dimensional polymeric network consisting poly(N-isopropylacrylamide) (pNIPAM) chains that are mechanically interlocked by a polyglycerol platform was synthesized and used for bacteria incapacitation. Two-dimensional hyperbranched polyglycerol (2D-hPG) was synthesized by a graphene-assisted strategy and used for encapsulation of azobisisobutyronitrile (AIBN). Radical polymerization of N-isopropylacrylamide by encapsulated AIBN resulted in thermoresponsive platforms with ~ 500 nm lateral size and 20–50 nm thickness. Due to its porous structure, 2D-PNPG was able to efficiently load antibiotics, such as tetracycline (TC) and amoxicillin (AMX). The rate of release of antibiotics from 2D-PNPG and the antibacterial activity of the system correlated with the variation of temperature as a result of the thermosensitivity of 2D-PNPG. This study shows that two-dimensional polymers are efficient platforms for future biomedical applications including drug delivery and bacteria incapacitation.

Graphical abstract

Thermoresponsive two-dimensional nanomaterials with the ability of loading therapeutic agents and antibacterial activity are synthesized and characterized.

中文翻译：

用于靶向药物输送的热响应抗菌二维聚甘油交联聚尼泮

二维聚合物网络是一类具有有趣的物理化学和生物特性的新型聚合物。由于其独特的功能，例如高表面积和纳米生物界面的多价相互作用，它们有望在未来广泛的生物医学应用，包括病原体相互作用、药物输送、生物成像、光热和光动力治疗。在这项工作中，合成了由聚（ N-异丙基丙烯酰胺）（pNIPAM）链组成的热敏二维聚合物网络，这些链通过聚甘油平台机械互锁，并用于细菌失能。通过石墨烯辅助策略合成二维超支化聚甘油（2D-hPG）并用于封装偶氮二异丁腈（AIBN）。 N-异丙基丙烯酰胺通过封装的 AIBN 进行自由基聚合，产生横向尺寸约 500 nm、厚度 20-50 nm 的热响应平台。由于其多孔结构，2D-PNPG能够有效负载抗生素，例如四环素（TC）和阿莫西林（AMX）。由于2D-PNPG的热敏感性，2D-PNPG的抗生素释放速率和系统的抗菌活性与温度的变化相关。这项研究表明，二维聚合物是未来生物医学应用（包括药物输送和细菌失能）的有效平台。