Photocatalytic antibacterial approach shows great potential in treating multidrug-resistant bacterial infections. However, the bactericidal efficiency heavily depends on the photocatalytic activity of semiconductor materials, which is limited by the fast recombination of photogenerated electron-hole pairs. Janus nano-heterostructures with spatial control growth of TiO₂ nanoparticles (NPs) at one end of gold nanorods (Au NRs) are designed via surface ligand regulation for photocatalytic sterilization and infected wound healing. The asymmetric nanostructure of Janus gold nanorod-titanium dioxide nanoparticles (Janus AuNR-TiO₂ NPs) promotes the directional migration of charge carriers and is more conducive to the spatial separation of electron—hole pairs. Moreover, the injection of hot electrons and enhancement of plasmon near-fields from the surface plasmon resonance (SPR) effect further improve the photocatalytic efficiency of Janus AuNR-TiO₂ NPs. Under simulated sunlight irradiation, large amounts of reactive oxygen species (ROS) are generated for photocatalytic antibacterial activity. Enhanced bactericidal efficiency up to 99.99% against methicillin-resistant Staphylococcus aureus (MRSA) is achieved in vitro. Furthermore, Janus AuNR-TiO₂ NPs exhibit superior biocompatibility, structural stability, and also remarkably accelerate MRSA-infected wound healing. Taking the above all into consideration, Janus AuNR-TiO₂ NPs, as an efficient antibacterial photocatalyst, offers a promising strategy for MRSA infectious therapy.

光催化抗菌方法在治疗多重耐药细菌感染方面显示出巨大潜力。然而，杀菌效率在很大程度上取决于半导体材料的光催化活性，这受到光生电子-空穴对快速复合的限制。Janus 纳米异质结构在金纳米棒 (Au NRs) 的一端具有空间控制生长的 TiO _{2纳米颗粒 (NPs) 是通过表面配体调节设计的，用于光催化消毒和感染伤口愈合。}Janus金纳米棒-二氧化钛纳米粒子（Janus AuNR-TiO _{2 ）的不对称纳米结构}NPs）促进电荷载流子的定向迁移，更有利于电子-空穴对的空间分离。此外，热电子的注入和表面等离子体共振（SPR）效应对等离子体近场的增强进一步提高了Janus AuNR-TiO ₂ NPs的光催化效率。在模拟阳光照射下，会产生大量活性氧（ROS）用于光催化抗菌活性。在体外对耐甲氧西林金黄色葡萄球菌(MRSA) 的杀菌效率提高了 99.99% 。此外，Janus AuNR-TiO ₂NPs 表现出优异的生物相容性、结构稳定性，并且还显着加速 MRSA 感染的伤口愈合。综上所述，Janus AuNR-TiO ₂ NPs 作为一种高效的抗菌光催化剂，为 MRSA 感染治疗提供了一种有前景的策略。