Some personal care products (PCPs) and their chemical components showed a hormetic effect in the freshwater photobacterium Vibrio qinghaiensis sp. -Q67 (Q67) after long-term exposure. However, how hormesis transfers between chemical components and PCP mixture, and which chemical component plays a major role remain unknown. To this end, according to the seven compounds detected in one skin lotion (SK5) and their concentration ratios, many mixture rays were constructed to simulate the SK5. Of these seven compounds, three presented monotonic concentration-response curves (CRC) to Q67 at 0.25 and 12 h (called a S-shaped compound). The other four compounds showed hormetic CRCs after 12 h and monotonic CRCs at 0.25 h (called a J-shaped compound). Based on their mixture ratios, we designed one ternary mixture ray of all S-shaped compounds, one quaternary mixture ray of all J-shaped compounds, and four quaternary mixture rays of one J-shaped and three S-shaped compounds. It was shown that SK5 could be approximately simulated by the mixture ray of the seven compounds detected in SK5 and only the mixture rays containing at least one hormesis-inducing compound produced hormesis to Q67 at 12 h. Based on the concentration ratios of various compounds and comparison of four hormetic characteristic parameters to those of various mixture rays, it was found that the compound betaine (BET) is a key compound affecting the hormesis of mixtures. Additionally, we studied the hormesis mechanism of BET on Q67 via quorum sensing (QS). This preliminarily indicated that the autoinducer-2 triggered the QS pathway. This study elucidated the transfer pattern of hormesis into mixtures, which would be an efficient method to identifying the potential components that affect hormesis transfer in mixtures. We expect that this study will provide new insights into hormesis and its mixtures.

一些个人护理产品 (PCP) 及其化学成分对淡水发光细菌青海弧菌具有兴奋作用sp。-Q67（Q67）长期接触后。然而，毒物兴奋作用如何在化学成分和 PCP 混合物之间转移，以及哪种化学成分起主要作用仍然未知。为此，根据一种护肤液（SK5）中检测到的七种化合物及其浓度比例，构建了多条混合射线来模拟SK5。在这七种化合物中，三种化合物在 0.25 和 12 小时时呈现出对 Q67 的单调浓度-响应曲线 (CRC)（称为 S 形化合物）。其他四种化合物在 12 小时后显示出强烈的 CRC，在 0.25 小时显示出单调的 CRC（称为 J 形化合物）。根据它们的混合比，我们设计了一种全S型化合物的三元混合射线，一种全J型化合物的四元混合射线，以及一种J型和三种S型化合物的四元混合射线。结果表明，SK5 中检测到的七种化合物的混合射线可以近似模拟 SK5，只有含有至少一种毒物兴奋诱导化合物的混合射线在 12 小时对 Q67 产生毒物兴奋作用。根据各种化合物的浓度比和四种药效特征参数与各种混合射线的比较，发现化合物甜菜碱(BET)是影响混合物药效的关键化合物。此外，我们通过群体感应 (QS) 研究了 BET 对 Q67 的兴奋机制。这初步表明autoinducer-2触发了QS通路。本研究阐明了毒物兴奋效应向混合物的转移模式，这将是识别影响混合物中毒物兴奋效应转移的潜在成分的有效方法。