通过聚唾液酸靶向纳米导弹对神经母细胞瘤进行光热治疗,Small

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通过聚唾液酸靶向纳米导弹对神经母细胞瘤进行光热治疗
Small ( IF 13.0 ) Pub Date : 2022-09-26 , DOI: 10.1002/smll.202201671
Shuxin Xu ₁ , Menghuan Zhao ₁ , Zikuan Gu ₁ , Haifeng Lu ₁ , Zhen Liu ₁

Affiliation

神经母细胞瘤治疗迫切需要探索新的靶点和开发新的靶向疗法。聚唾液酸 (polySia) 是一种唾液酸单元的线性均聚物，与肿瘤进展和不良预后密切相关，已成为神经母细胞瘤的潜在靶标。然而，缺乏 polySia 特异性结合试剂严重限制了针对神经母细胞瘤的 polySia 靶向疗法的发展。在此，报道了通过分子印迹构建 polySia 靶向纳米导弹用于神经母细胞瘤的光热治疗。含有 3-4 个单元的低聚唾液酸 (oligoSia) 被认为是识别 polySia 的特征结构，而含有从 polySia 消化的 4-7 个单元的 oligoSia 被用作模板。通过硼酸盐亲和可控的定向表面印迹，准备了 oSia-印记纳米粒子 (oSia-MIP)。oSia-MIP 允许在体外和体内特异性识别 polySia 并靶向 polySia 过度表达的神经母细胞瘤细胞。载有吲哚菁绿的 oSia-MIP 已制备并通过实验证明是神经母细胞瘤的有效靶向光热疗法。为核心基板配备功能实体，开发的 polySia 靶向纳米平台可以适应各种治疗方式，为神经母细胞瘤靶向治疗带来巨大希望。载有吲哚菁绿的 oSia-MIP 已制备并通过实验证明是神经母细胞瘤的有效靶向光热疗法。为核心基板配备功能实体，开发的 polySia 靶向纳米平台可以适应各种治疗方式，为神经母细胞瘤靶向治疗带来巨大希望。载有吲哚菁绿的 oSia-MIP 已制备并通过实验证明是神经母细胞瘤的有效靶向光热疗法。为核心基板配备功能实体，开发的 polySia 靶向纳米平台可以适应各种治疗方式，为神经母细胞瘤靶向治疗带来巨大希望。

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Photothermal Therapy of Neuroblastoma via Polysialic Acid-Targeting Nanomissiles

Exploring new targets and developing novel targeted therapies are urgently needed for neuroblastoma therapy. Polysialic acid (polySia), a linear homopolymer of sialic acid units that correlates well with tumor progression and poor prognosis, has emerged as a potential target for neuroblastoma. However, the lack of polySia-specific binding reagents has severely limited the development of polySia-targeting therapeutics for neuroblastoma. Herein, the construction of polySia-targeting nanomissiles via molecular imprinting for the photothermal therapy of neuroblastoma is reported. Oligosialic acid (oligoSia) containing 3–4 units is considered as a characteristic structure for the recognition of polySia, while oligoSia containing 4–7 units digested from polySia is employed as the template. Via boronate-affinity controllable oriented surface imprinting, oligoSia-imprinted nanoparticles (oSia-MIP) are prepared. The oSia-MIP allows for specifically recognizing polySia and targeting polySia overexpressed neuroblastoma cells in vitro and in vivo. oSia-MIP loaded with indocyanine green is prepared and experimentally demonstrated to be a potent targeted photothermal therapeutic for neuroblastoma. Equipping the core substrate with functional entities, the developed polySia targeting nanoplatform can be accommodated to various therapeutic modalities, holding great promise for neuroblastoma targeted therapy.

更新日期：2022-09-26

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