Developing Isoxazole as a Native Photo-Cross-Linker for Photoaffinity Labeling and Chemoproteomics,Angewandte Chemie International Edition

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Developing Isoxazole as a Native Photo-Cross-Linker for Photoaffinity Labeling and Chemoproteomics
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-09-23 , DOI: 10.1002/anie.202209947
Ke Cheng _{1,

2} , Junyang Qi ₂ , Xiaojie Ren ₁ , Jie Zhang ₁ , Huangxu Li ₁ , Hanyue Xiao ₁ , Rui Wang ₃ , Zhiyang Liu ₁ , Lingkuan Meng ₁ , Nan Ma _{4,

5} , Hongyan Sun ₁

Affiliation

Isoxazole is an essential pharmacophore in drug discovery. In this study, we investigated the photochemistry of isoxazole with biomolecules and developed it as a natively embedded photo-cross-linker for chemoproteomics and drug discovery. With this strategy, two isoxazole-containing drugs were successfully applied to chemoproteomic platforms to uncover their cellular targets and interactions.

中文翻译：

开发异恶唑作为用于光亲和标记和化学蛋白质组学的天然光交联剂

异恶唑是药物发现中必不可少的药效团。在这项研究中，我们研究了异恶唑与生物分子的光化学，并将其开发为一种天然嵌入的光交联剂，用于化学蛋白质组学和药物发现。通过这种策略，两种含异恶唑的药物成功应用于化学蛋白质组学平台，以揭示它们的细胞靶点和相互作用。

更新日期：2022-09-23

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