Photo-crosslinkable methacrylated konjac glucomannan (KGMMA) hydrogels as a promising bioink for 3D bioprinting,Biomaterials Science

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Photo-crosslinkable methacrylated konjac glucomannan (KGMMA) hydrogels as a promising bioink for 3D bioprinting
Biomaterials Science ( IF 5.8 ) Pub Date : 2022-09-24 , DOI: 10.1039/d2bm00832g
Zainen Qin _{1,

2} , Yunfen Pang ₁ , Chun Lu ₃ , YiFeng Yang ₁ , Ming Gao _{1,

2} , Li Zheng _{1,

2,

4} , Jinmin Zhao _{1,

2,

4,

5}

Affiliation

Three-dimensional (3D) bioink with favorable printability, strength, and biocompatibility challenged the 3D bioprinting technology in cartilage tissue engineering. Herein, we innovatively fabricated photo-crosslinkable methacrylated konjac glucomannan (KGMMA) as a novel biomaterial ink for 3D extrusion bioprinting in an attempt to construct precisely patterned tissues. Specifically, konjac glucomannan (KGM) was modified by methacrylic anhydride, which is a kind of photoreactive group, to form KGMMA. After UV crosslinking, the printed KGMMA hydrogel formed a covalent crosslinking network with high strength, desired shearing, and swelling and degradation characteristics. The properties of the KGMMA hydrogel could be modulated by changing the contents of MA. The shear-thinning property of the KGMMA biomaterial ink enables excellent printability, which can print different shapes including lattices, hexagons, and flowers. Furthermore, the bioinks support cell growth after being printed with chondrocytes for a culture. Therefore, the biodegradable, injectable, and photo-crosslinkable KGMMA biomaterial ink holds a great promise for cartilage tissue engineering.

中文翻译：

可光交联的甲基丙烯酸化魔芋葡甘聚糖 (KGMMA) 水凝胶作为用于 3D 生物打印的有前途的生物墨水

具有良好可印刷性、强度和生物相容性的三维 (3D) 生物墨水对软骨组织工程中的 3D 生物打印技术提出了挑战。在此，我们创新地制造了可光交联的甲基丙烯酸化魔芋葡甘聚糖 (KGMMA) 作为用于 3D 挤出生物打印的新型生物材料墨水，以尝试构建精确图案化的组织。具体而言，魔芋葡甘聚糖（KGM）通过甲基丙烯酸酐（一种光反应性基团）改性形成KGMMA。UV交联后，印刷的KGMMA水凝胶形成了具有高强度、所需剪切、溶胀和降解特性的共价交联网络。KGMMA 水凝胶的性质可以通过改变 MA 的含量来调节。KGMMA 生物材料墨水的剪切稀化特性可实现出色的印刷适性，它可以打印不同的形状，包括格子、六边形和花朵。此外，生物墨水在印有用于培养的软骨细胞后支持细胞生长。因此，可生物降解、可注射和可光交联的 KGMMA 生物材料墨水对软骨组织工程具有很大的应用前景。

更新日期：2022-09-24

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