Ginkgolides are diterpenes isolated from Ginkgo biloba that exhibit strong anti-inflammatory and neuroprotective properties. The highly complex molecular architecture of ginkgolides, combined with their remarkable biological profile, provides a unique platform for the development of new strategies and methods. Herein, we reported the first total synthesis of ginkgolide C and the formal syntheses of ginkgolides A and B. Our synthesis is based on a functional group strategy guided by the compact structure of ginkgolide, where a series of diastereoselective carbon–carbon bond formations and oxidations are carefully orchestrated.

中文翻译：

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银杏内酯 C 的全合成和银杏内酯 A 和 B 的正式合成

银杏内酯是从银杏叶中分离出来的二萜，具有很强的抗炎和神经保护作用。银杏内酯高度复杂的分子结构，结合其卓越的生物学特性，为开发新的策略和方法提供了独特的平台。在此，我们报道了银杏内酯 C 的首次全合成以及银杏内酯 A 和 B 的正式合成。我们的合成基于银杏内酯紧凑结构指导的官能团策略，其中一系列非对映选择性碳-碳键形成和氧化是精心编排的。