An efficient new synthesis of a peroxisome proliferator-activated receptor delta agonist fonadelpar was developed. The new process features a more practical approach to construct the ethylene linker of fonadelpar by coupling an advanced aldehyde and a ketone via Claisen–Schmidt condensation, which is followed by hydrogenation and an optimized process to obtain the isoxazole moiety. The convergent synthesis provides a robust and scalable approach to prepare the drug candidate in significantly fewer steps and with a higher yield.

中文翻译：

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开发 PPARδ 激动剂 Fonadelpar 的有效新途径：通过 Claisen 缩合形成 C-C 键

开发了一种有效的新合成过氧化物酶体增殖物激活受体 δ 激动剂 fonadelpar。新工艺的特点是通过克莱森-施密特缩合偶联高级醛和酮，然后进行氢化和优化工艺以获得异恶唑部分，从而构建福纳地帕的乙烯接头。聚合合成提供了一种稳健且可扩展的方法，以显着更少的步骤和更高的产率制备候选药物。