用于快速胃穿孔和创伤性气胸密封的速干粘合剂,Advanced Healthcare Materials

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用于快速胃穿孔和创伤性气胸密封的速干粘合剂
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2022-09-23 , DOI: 10.1002/adhm.202201798
Xiaowei Liu ₁ , Ying Yang ₂ , Haojie Yu ₁ , Li Wang ₁ , Yan Sheng ₃ , Zhikun Huang ₁ , Jian Yang ₁ , Zhipeng Ni ₁ , Di Shen ₁

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水凝胶粘合剂因其无处不在和实际相关性而成为热点。然而，由于界面流体和散装水凝胶以及目标基材之间优先形成氢键，因此实现牢固的湿附着力仍然是一个挑战。在此，报道了一种由丝素蛋白 (SF) 半互穿网络和聚（丙烯酸）共价网络组成的半干粘合剂，它可以实现快速的液体吸附和遇到湿组织的排斥过程。剩余的水使动态表面具有出色的水凝胶柔韧性，而β折叠在剥离过程中赋予其坚韧的体积强度。值得注意的是，与猪皮的湿粘附能为 1440 J m ^-2由于来自 SF 的氢键、静电相互作用和链缠结的组合。特别是，体外和体内结果均表明具有出色的止血效果，并导致皮肤、动脉、胃穿孔和肺的切口闭合。第一阶段闭合后，聚丙烯酸-丝素蛋白粘合剂 (PSA) 密封剂可以从肺表面脱离，非常适合愈合期。凭借可靠的粘附性和良好的非细胞毒性，PSA 可能成为组织密封剂和药物载体应用的潜在候选者。

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Instant and Tough Adhesives for Rapid Gastric Perforation and Traumatic Pneumothorax Sealing

Hydrogel adhesives are hot spots due to their ubiquity and practical relevance. However, achieving a robust wet adhesion is still a challenge due to the preferential formation of hydrogen bonds between interfacial fluids and bulk hydrogel, as well as targeted substrates. Herein, a half-dry adhesive consisting of a silk fibroin (SF) semi-interpenetrating network and poly(acrylic acid) covalent network, which can allow a rapid liquid adsorption and repulsion process encountering a wet tissue, is reported. The remaining water enables excellent hydrogel flexibility to a dynamic surface, while the β-sheet fold endows its tough bulk strength under the peeling-off process. Notably, the wet adhesion energy versus porcine skin is 1440 J m⁻² due to the combination of hydrogen bonds, electrostatic interactions, and chain entanglement derived from SF. In particular, both in vitro and in vivo outcomes indicate excellent hemostatic effects and result in incision closure of skin, artery, gastric perforation, and lung. After the first-stage closure, polyacrylic-silk fibroin adhesive (PSA) sealants can detach from the lung surface, fitting well to the healing period. By virtue of the reliable adhesion and good noncytotoxicity, PSA may be a prospective candidate for tissue sealant and drug carrier applications.

更新日期：2022-09-23

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