Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment with remarkable cellular and spatial heterogeneity that meaningfully impacts disease biology and treatment resistance. Recent advances in tissue imaging capabilities, single-cell analytics, and disease modeling have shed light on organizing principles that shape the stromal complexity of PDAC tumors. These insights into the functional and spatial dependencies that coordinate cancer cell biology and the relationships that exist between cells and extracellular matrix components present in tumors are expected to unveil therapeutic vulnerabilities. We review recent advances in the field and discuss current understandings of mechanisms by which the tumor microenvironment shapes PDAC pathogenesis and therapy resistance.

中文翻译：

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胰腺癌发病机制和治疗耐药中的肿瘤微环境


胰腺导管腺癌 （PDAC） 具有突出的基质微环境，具有显着的细胞和空间异质性，对疾病生物学和治疗耐药性产生重大影响。组织成像能力、单细胞分析和疾病建模的最新进展揭示了塑造 PDAC 肿瘤基质复杂性的组织原理。这些对协调癌细胞生物学的功能和空间依赖性以及肿瘤中存在的细胞与细胞外基质成分之间存在的关系的见解有望揭示治疗脆弱性。我们回顾了该领域的最新进展，并讨论了目前对肿瘤微环境塑造 PDAC 发病机制和治疗耐药机制的理解。