A Charge-Neutral Self-Assembled L2Zn2 Helicate as Bench-Stable Receptor for Anion Recognition at Nanomolar Concentration,Journal of the American Chemical Society

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A Charge-Neutral Self-Assembled L2Zn2 Helicate as Bench-Stable Receptor for Anion Recognition at Nanomolar Concentration
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2022-09-22 , DOI: 10.1021/jacs.2c08579
David Van Craen ₁ , Malavika G Kalarikkal ₁ , Julian J Holstein ₁

Affiliation

The field of anion recognition chemistry is dominated by two fundamental approaches to design receptors. One relies on the formation of covalent bonds resulting in organic and often neutral host species, while the other one utilizes metal-driven self-assembly for the formation of charged receptors with well-defined nanocavities. Yet, the combination of their individual advantages in the form of charge-neutral metal-assembled bench-stable anion receptors is severely lacking. Herein, we present a fluorescent and uncharged double-stranded hydroxyquinoline-based zinc(II) helicate with the ability to bind environmentally relevant dicarboxylate anions with high fidelity in dimethyl sulfoxide (DMSO) at nanomolar concentrations. These dianions are pinned between zinc(II) centers with binding constants up to 145 000 000 M^–1. The presented investigation exemplifies a pathway to bridge the two design approaches and combine their strength in one structural motif as an efficient anion receptor.

中文翻译：

电荷中性自组装 L2Zn2 螺旋体作为纳米摩尔浓度阴离子识别的稳定受体

阴离子识别化学领域主要由两种设计受体的基本方法主导。一种依赖于形成有机且通常是中性的宿主物质的共价键，而另一种利用金属驱动的自组装形成具有明确纳米腔的带电受体。然而，它们以电荷中性金属组装的台式稳定阴离子受体的形式结合各自的优势是严重缺乏的。在此，我们提出了一种荧光且不带电的双链羟基喹啉基锌 (II) 螺旋体，它能够以纳摩尔浓度在二甲基亚砜 (DMSO) 中以高保真度结合环境相关的二羧酸根阴离子。这些双阴离子被固定在锌 (II) 中心之间，结合常数高达 145 000 000 M ^–1. 所提出的研究举例说明了一种连接两种设计方法并将它们的强度结合在一个结构基序中作为有效阴离子受体的途径。

更新日期：2022-09-22

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