Acute lung injury (ALI) is triggered by an acute inflammatory response. Lipopolysaccharide (LPS) is recognized as an important participant in the pathogenesis of sepsis, which may induce ALI. N-phenethyl-5-phenylpicolinamide (N5P) is a newly synthesized HIF-1α inhibitor. The purpose of the present study was to investigate the potential protective effects of N5P on LPS-induced ALI and the underlying mechanisms.

中文翻译：

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N-苯乙基-5-苯基磷酰胺通过抑制 HIF-1α/糖酵解/ASIC1a 通路减轻急性肺损伤的炎症


急性肺损伤 （ALI） 是由急性炎症反应引发的。脂多糖 （LPS） 被认为是脓毒症发病机制的重要参与者，脓毒症可能诱发 ALI。N-苯乙基-5-苯基磷酰胺 （N5P） 是一种新合成的 HIF-1α 抑制剂。本研究的目的是探讨 N5P 对 LPS 诱导的 ALI 的潜在保护作用及其潜在机制。