A new diterpenoid glucoside, 15,16-dihydroxy-4-formyl-neo-clerodane-3,13 (Z)-dien-17-O-β-Dglucopyranosyl (1), was isolated from Sheareria nana S. Moore. The structure was elucidated by spectroscopic data. 1 was evaluated for cytotoxic activities against human endometrial carcinoma cells (Ishikawa and ECC-1). The results suggested that 1 exhibited moderate cytotoxic activity against Ishikawa and ECC-1 cell lines with IC50 values of 6.6 ± 0.2 and 12.1 ± 0.1 μM for 24 h respectively, whereas 1 showed no cytotoxicity against a human hepatocyte cell line. Thus, 1 was a potential choice for the treatment of endometrial carcinoma.

从 Sheareria nana S. Moore 中分离出一种新的二萜糖苷，15,16-dihydroxy-4-formyl-neo-clerodane-3,13 (Z)-dien-17-O-β-Dglucopyranosyl ( 1 )。该结构由光谱数据阐明。1评估了对人子宫内膜癌细胞（Ishikawa 和 ECC-1）的细胞毒活性。结果表明，1对 Ishikawa 和 ECC-1 细胞系表现出中等的细胞毒活性，24 小时 IC50 值分别为 6.6 ± 0.2 和 12.1 ± 0.1 μM，而1对人肝细胞系没有细胞毒性。因此，1是治疗子宫内膜癌的潜在选择。